Interaction between Serotonin Transporter and Serotonin Receptor 1 B genes polymorphisms may be associated with antisocial alcoholism

Tzu Yun Wang, Sheng Yu Lee, Shiou Lan Chen, Yun Hsuan Chang, Shih Heng Chen, Chun Hsien Chu, San Yuan Huang, Nian Sheng Tzeng, Chen Lin Wang, I. H. Lee, Tzung L. Yeh, Yen K. Yang, Ru Band Lu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Several studies have hypothesized that genes regulating the components of the serotonin system, including serotonin transporter (5-HTTLPR) and serotonin 1 B receptor (5-HT1B), may be associated with alcoholism, but their results are contradictory because of alcoholism's heterogeneity. Therefore, we examined whether the 5-HTTLPR gene and 5-HT1B gene G861C polymorphism are susceptibility factors for a specific subtype of alcoholism, antisocial alcoholism in Han Chinese in Taiwan.Methods: We recruited 273 Han Chinese male inmates with antisocial personality disorder (ASPD) [antisocial alcoholism (AS-ALC) group (n = 120) and antisocial non-alcoholism (AS-N-ALC) group (n = 153)] and 191 healthy male controls from the community. Genotyping was done using PCR-RFLP.Results: There were no significant differences in the genotypic frequency of the 5-HT1B G861C polymorphism between the 3 groups. Although AS-ALC group members more frequently carried the 5-HTTLPR S/S, S/L G, and L G/L G genotypes than controls, the difference became non-significant after controlling for the covarying effects of age. However, the 5-HTTLPR S/S, S/L G, and L G/L G genotypes may have interacted with the 5-HT1B G861C C/C polymorphism and increased the risk of becoming antisocial alcoholism.Conclusion: Our study suggests that neither the 5-HTTLPR gene nor the 5-HT1B G861C polymorphism alone is a risk factor for antisocial alcoholism in Taiwan's Han Chinese population, but that the interaction between both genes may increase susceptibility to antisocial alcoholism.

Original languageEnglish
Article number18
JournalBehavioral and Brain Functions
Volume8
DOIs
Publication statusPublished - 2012 May 2

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience
  • Biological Psychiatry
  • Behavioral Neuroscience

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