Interfacial interactions between natural RBC membranes and synthetic polymeric nanoparticles

Brian T. Luk, Che Ming Jack Hu, Ronnie H. Fang, Diana Dehaini, Cody Carpenter, Weiwei Gao, Liangfang Zhang

Research output: Contribution to journalArticlepeer-review

140 Citations (Scopus)

Abstract

The unique structural features and stealth properties of a recently developed red blood cell membrane-cloaked nanoparticle (RBC-NP) platform raise curiosity over the interfacial interactions between natural cellular membranes and polymeric nanoparticle substrates. Herein, several interfacial aspects of the RBC-NPs are examined, including completeness of membrane coverage, membrane sidedness upon coating, and the effects of polymeric particles' surface charge and surface curvature on the membrane cloaking process. The study shows that RBC membranes completely cover negatively charged polymeric nanoparticles in a right-side-out manner and enhance the particles' colloidal stability. The membrane cloaking process is applicable to particle substrates with a diameter ranging from 65 to 340 nm. Additionally, the study reveals that both surface glycans on RBC membranes and the substrate properties play a significant role in driving and directing the membrane-particle assembly. These findings further the understanding of the dynamics between cellular membranes and nanoscale substrates and provide valuable information toward future development and characterization of cellular membrane-cloaked nanodevices.

Original languageEnglish
Pages (from-to)2730-2737
Number of pages8
JournalNanoscale
Volume6
Issue number5
DOIs
Publication statusPublished - 2014 Mar 7

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

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