Interference with uterine blood flow by clomiphene citrate in women with unexplained infertility

Chao Chin Hsu, Hong Chang Kuo, Shan-Tair Wang, Ko En Huang

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

To investigate the effect of clomiphene citrate on the uterine blood flow in women with unexplained infertility. Twenty-one women who had normal uterine blood flow (pulsatility index [PI]less than 3 from the LH peak to the middle luteal phase of a natural ovulatory cycle) were enrolled in this study. Patients were given clomiphene citrate (100 mg/day) from days 5–9 of the next ovulatory cycle. The PI values measured in the natural and clomiphene citrate-treated cycles were compared using repeated measures analysis of variance. Their correlations with the estradiol (E2) and progesterone concentrations in the treatment cycle were calculated using the Pearson correlation coefficient. In the natural cycles of those with normal uterine blood flow, the highest impedance of uterine blood flow was detected at the late follicular phase, then blood flow increased during the luteal phase. In the clomiphene citratetreated cycles, a statistically significant decrease in uterine blood flow also occurred during the early luteal phase (P < .05). No significant correlation of E2 or progesterone serum concentrations with PI values of the uterine artery could be found in either natural or clomiphene citrate-treated cycles. The use of clomiphene citrate decreases the uterine blood flow during the early luteal phase, a periimplantation stage.

Original languageEnglish
Pages (from-to)917-921
Number of pages5
JournalObstetrics and Gynecology
Volume86
Issue number6
DOIs
Publication statusPublished - 1995 Jan 1

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Clomiphene
Infertility
Luteal Phase
Progesterone
Uterine Artery
Follicular Phase
Electric Impedance
Estradiol
Analysis of Variance
Serum

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Hsu, Chao Chin ; Kuo, Hong Chang ; Wang, Shan-Tair ; Huang, Ko En. / Interference with uterine blood flow by clomiphene citrate in women with unexplained infertility. In: Obstetrics and Gynecology. 1995 ; Vol. 86, No. 6. pp. 917-921.
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Interference with uterine blood flow by clomiphene citrate in women with unexplained infertility. / Hsu, Chao Chin; Kuo, Hong Chang; Wang, Shan-Tair; Huang, Ko En.

In: Obstetrics and Gynecology, Vol. 86, No. 6, 01.01.1995, p. 917-921.

Research output: Contribution to journalArticle

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