Interleukin-1β gene is not associated with preeclampsia in Taiwanese

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Objective: To identify associations between the interleukin-1β gene and preeclampsia in Taiwanese women. Methods and Materials: We genotyped Taiwanese population (102 women with preeclampsia and 148 controls) for two polymorphisms of the interleukin-1β gene (promoter region and Exon 5) by using polymerase chain reaction and restriction fragment length polymorphism analysis. The association between the genotype and disease was examined by Chi-square tests. Results: We found no association between the two polymorphic sites of interleukin-1β gene and preeclampsia. No significant differences were detected in genotype distributions and allele frequencies of the AvaI polymorphism at position -511 in the promoter region and the TaqI polymorphism at position +3953 within Exon 5. Conclusion: Our data do not support a role of the interleukin-1β gene in the pathogenesis of preeclampsia in Taiwanese women.

Original languageEnglish
Pages (from-to)240-244
Number of pages5
JournalTaiwanese Journal of Obstetrics and Gynecology
Issue number2
Publication statusPublished - 2012 Jun

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

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