Interleukin-17-producing cell infiltration in the breast cancer tumour microenvironment is a poor prognostic factor

Wen Chung Chen, Yu Hsuan Lai, Hung Yu Chen, How Ran Guo, Ih Jen Su, Helen H.W. Chen

Research output: Contribution to journalArticle

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Abstract

Aims: Interleukin-17 (IL-17) is a proinflammatory cytokine that is most prominently produced by T-helper type 17 (Th17) cells, a distinct CD4+ T-helper cell subset. The aim of this study was to investigate the level of IL-17-producing cells in the breast cancer tumour microenvironment and its prognostic role. Methods and results: A total of 207 breast carcinoma specimens were assessed by IL-17 immunohistochemistry, and the findings were correlated with clinicopathological parameters. We found that increased numbers of IL-17-producing cells were correlated with high histological grade, negative ER/PR status, and triple-negative molecular subtypes segregated by immunoprofiles. However, they did not correlate with stage, tumour size, nodal status, HER2 status, or histological type. Patients with tumours with high numbers of IL-17-producing cells had shorter disease-free survival (DFS) than patients with tumours with low numbers of IL-17-producing cells (P < 0.01). In multivariate analysis, high IL-17 level [hazard ratio (HR) 2.24; 95% CI 1.06-4.75], advanced T stage (HR 2.73; 95% CI 1.30-5.73), positive HER2 status (HR 4.88; 95% CI 1.47-16.18) and triple-negative subtype (HR 7.46; 95% CI 1.38-40.36) were significant prognostic factors for DFS. Conclusions: Our results indicate that a high level of IL-17-producing cells in the breast cancer tumour microenvironment is a poor prognostic factor.

Original languageEnglish
Pages (from-to)225-233
Number of pages9
JournalHistopathology
Volume63
Issue number2
DOIs
Publication statusPublished - 2013 Aug 1

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Tumor Microenvironment
Interleukin-17
Breast Neoplasms
Disease-Free Survival
Th17 Cells
Neoplasms
T-Lymphocyte Subsets
Multivariate Analysis
Immunohistochemistry
Cytokines

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

Cite this

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title = "Interleukin-17-producing cell infiltration in the breast cancer tumour microenvironment is a poor prognostic factor",
abstract = "Aims: Interleukin-17 (IL-17) is a proinflammatory cytokine that is most prominently produced by T-helper type 17 (Th17) cells, a distinct CD4+ T-helper cell subset. The aim of this study was to investigate the level of IL-17-producing cells in the breast cancer tumour microenvironment and its prognostic role. Methods and results: A total of 207 breast carcinoma specimens were assessed by IL-17 immunohistochemistry, and the findings were correlated with clinicopathological parameters. We found that increased numbers of IL-17-producing cells were correlated with high histological grade, negative ER/PR status, and triple-negative molecular subtypes segregated by immunoprofiles. However, they did not correlate with stage, tumour size, nodal status, HER2 status, or histological type. Patients with tumours with high numbers of IL-17-producing cells had shorter disease-free survival (DFS) than patients with tumours with low numbers of IL-17-producing cells (P < 0.01). In multivariate analysis, high IL-17 level [hazard ratio (HR) 2.24; 95{\%} CI 1.06-4.75], advanced T stage (HR 2.73; 95{\%} CI 1.30-5.73), positive HER2 status (HR 4.88; 95{\%} CI 1.47-16.18) and triple-negative subtype (HR 7.46; 95{\%} CI 1.38-40.36) were significant prognostic factors for DFS. Conclusions: Our results indicate that a high level of IL-17-producing cells in the breast cancer tumour microenvironment is a poor prognostic factor.",
author = "Chen, {Wen Chung} and Lai, {Yu Hsuan} and Chen, {Hung Yu} and Guo, {How Ran} and Su, {Ih Jen} and Chen, {Helen H.W.}",
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Interleukin-17-producing cell infiltration in the breast cancer tumour microenvironment is a poor prognostic factor. / Chen, Wen Chung; Lai, Yu Hsuan; Chen, Hung Yu; Guo, How Ran; Su, Ih Jen; Chen, Helen H.W.

In: Histopathology, Vol. 63, No. 2, 01.08.2013, p. 225-233.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Interleukin-17-producing cell infiltration in the breast cancer tumour microenvironment is a poor prognostic factor

AU - Chen, Wen Chung

AU - Lai, Yu Hsuan

AU - Chen, Hung Yu

AU - Guo, How Ran

AU - Su, Ih Jen

AU - Chen, Helen H.W.

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N2 - Aims: Interleukin-17 (IL-17) is a proinflammatory cytokine that is most prominently produced by T-helper type 17 (Th17) cells, a distinct CD4+ T-helper cell subset. The aim of this study was to investigate the level of IL-17-producing cells in the breast cancer tumour microenvironment and its prognostic role. Methods and results: A total of 207 breast carcinoma specimens were assessed by IL-17 immunohistochemistry, and the findings were correlated with clinicopathological parameters. We found that increased numbers of IL-17-producing cells were correlated with high histological grade, negative ER/PR status, and triple-negative molecular subtypes segregated by immunoprofiles. However, they did not correlate with stage, tumour size, nodal status, HER2 status, or histological type. Patients with tumours with high numbers of IL-17-producing cells had shorter disease-free survival (DFS) than patients with tumours with low numbers of IL-17-producing cells (P < 0.01). In multivariate analysis, high IL-17 level [hazard ratio (HR) 2.24; 95% CI 1.06-4.75], advanced T stage (HR 2.73; 95% CI 1.30-5.73), positive HER2 status (HR 4.88; 95% CI 1.47-16.18) and triple-negative subtype (HR 7.46; 95% CI 1.38-40.36) were significant prognostic factors for DFS. Conclusions: Our results indicate that a high level of IL-17-producing cells in the breast cancer tumour microenvironment is a poor prognostic factor.

AB - Aims: Interleukin-17 (IL-17) is a proinflammatory cytokine that is most prominently produced by T-helper type 17 (Th17) cells, a distinct CD4+ T-helper cell subset. The aim of this study was to investigate the level of IL-17-producing cells in the breast cancer tumour microenvironment and its prognostic role. Methods and results: A total of 207 breast carcinoma specimens were assessed by IL-17 immunohistochemistry, and the findings were correlated with clinicopathological parameters. We found that increased numbers of IL-17-producing cells were correlated with high histological grade, negative ER/PR status, and triple-negative molecular subtypes segregated by immunoprofiles. However, they did not correlate with stage, tumour size, nodal status, HER2 status, or histological type. Patients with tumours with high numbers of IL-17-producing cells had shorter disease-free survival (DFS) than patients with tumours with low numbers of IL-17-producing cells (P < 0.01). In multivariate analysis, high IL-17 level [hazard ratio (HR) 2.24; 95% CI 1.06-4.75], advanced T stage (HR 2.73; 95% CI 1.30-5.73), positive HER2 status (HR 4.88; 95% CI 1.47-16.18) and triple-negative subtype (HR 7.46; 95% CI 1.38-40.36) were significant prognostic factors for DFS. Conclusions: Our results indicate that a high level of IL-17-producing cells in the breast cancer tumour microenvironment is a poor prognostic factor.

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