Interleukin-20 targets renal mesangial cells and is associated with lupus nephritis

Hsing Hui Li, He Hsiung Cheng, Kuang Hui Sun, Chi Chen Wei, Chien Feng Li, Wen Chung Chen, Wen Mein Wu, Ming Shi Chang

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Lupus nephritis is one manifestation of systemic lupus erythematosus (SLE). Interleukin (IL)-10 is involved in the pathogenesis of SLE. To determine whether IL-20, a member of the IL-10 family, is associated with lupus nephritis, we analyzed the expression of IL-20 and its receptors in mesangial cells derived from SLE-prone, NZB/W, and DBA/W mice. IL-20 and its receptors were upregulated in mesangial cells from NZB/W mice. Incubating IL-20 with mesangial cells upregulated the transcripts of CCL2 (MCP-1), CCL5 (RANTES), CXCL10 (IP-10), IL-6, iNOS, and ROS, all of which are involved in the pathogenesis of lupus nephritis. IL-20 specifically activated the downstream signal ERK 1/2. We also detected human IL-20 protein in both mesangial cells and inflammatory cells in kidney biopsies of patients with lupus nephritis. Our results reveal the novel effects of IL-20 on mesangial cells and its association with lupus nephritis.

Original languageEnglish
Pages (from-to)277-285
Number of pages9
JournalClinical Immunology
Volume129
Issue number2
DOIs
Publication statusPublished - 2008 Nov 1

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Lupus Nephritis
Mesangial Cells
Systemic Lupus Erythematosus
Interleukin-10
Inbred NZB Mouse
Chemokine CCL5
Inbred DBA Mouse
Interleukin-6
interleukin 20
Kidney
Biopsy

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Li, Hsing Hui ; Cheng, He Hsiung ; Sun, Kuang Hui ; Wei, Chi Chen ; Li, Chien Feng ; Chen, Wen Chung ; Wu, Wen Mein ; Chang, Ming Shi. / Interleukin-20 targets renal mesangial cells and is associated with lupus nephritis. In: Clinical Immunology. 2008 ; Vol. 129, No. 2. pp. 277-285.
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abstract = "Lupus nephritis is one manifestation of systemic lupus erythematosus (SLE). Interleukin (IL)-10 is involved in the pathogenesis of SLE. To determine whether IL-20, a member of the IL-10 family, is associated with lupus nephritis, we analyzed the expression of IL-20 and its receptors in mesangial cells derived from SLE-prone, NZB/W, and DBA/W mice. IL-20 and its receptors were upregulated in mesangial cells from NZB/W mice. Incubating IL-20 with mesangial cells upregulated the transcripts of CCL2 (MCP-1), CCL5 (RANTES), CXCL10 (IP-10), IL-6, iNOS, and ROS, all of which are involved in the pathogenesis of lupus nephritis. IL-20 specifically activated the downstream signal ERK 1/2. We also detected human IL-20 protein in both mesangial cells and inflammatory cells in kidney biopsies of patients with lupus nephritis. Our results reveal the novel effects of IL-20 on mesangial cells and its association with lupus nephritis.",
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Li, HH, Cheng, HH, Sun, KH, Wei, CC, Li, CF, Chen, WC, Wu, WM & Chang, MS 2008, 'Interleukin-20 targets renal mesangial cells and is associated with lupus nephritis', Clinical Immunology, vol. 129, no. 2, pp. 277-285. https://doi.org/10.1016/j.clim.2008.07.006

Interleukin-20 targets renal mesangial cells and is associated with lupus nephritis. / Li, Hsing Hui; Cheng, He Hsiung; Sun, Kuang Hui; Wei, Chi Chen; Li, Chien Feng; Chen, Wen Chung; Wu, Wen Mein; Chang, Ming Shi.

In: Clinical Immunology, Vol. 129, No. 2, 01.11.2008, p. 277-285.

Research output: Contribution to journalArticle

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