Interleukin-6 as an Early Chronic Inflammatory Marker in Polycystic Ovary Syndrome with Insulin Receptor Substrate-2 Polymorphism

Yue Shan Lin, Shaw-Jenq Tsai, Ming Wei Lin, Cheng Ta Yang, Mei Feng Huang, Meng-Hsing Wu

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Problem Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disorder. This study was to evaluate whether insulin receptor substrate (IRS)-2 Gly1057Asp polymorphism influences chronic inflammatory parameters in Taiwanese patients with PCOS. Method of study DNA was extracted from whole blood samples for genotyping and detection of IRS-2 Gly1057Asp polymorphism in 129 PCOS women and 109 control women. Ninety-seven PCOS women accepted metformin treatment for 3months, and low-grade chronic inflammatory markers were assessed. Results The levels of IL-6 were significantly elevated in PCOS women compared with normal women. Among allelic variant of IRS-2, concentrations of IL-6 were greater in IRS-2 homozygous Asp population. Treatment with metformin significantly reduced IL-6, especially in PCOS patients with IRS-2 homozygous Asp variant. Conclusion The results showed that IL-6 may be an early low-grade chronic inflammatory marker among PCOS patients with IRS-2 polymorphism in Taiwanese population. This pharmacologic study in IRS-2 polymorphism may provide more information for preventing long-term complications in PCOS.

Original languageEnglish
Pages (from-to)527-533
Number of pages7
JournalAmerican Journal of Reproductive Immunology
Volume66
Issue number6
DOIs
Publication statusPublished - 2011 Dec 1

Fingerprint

Insulin Receptor Substrate Proteins
Polycystic Ovary Syndrome
Interleukin-6
Metformin
Viperidae
Population
DNA
Therapeutics

All Science Journal Classification (ASJC) codes

  • Immunology
  • Immunology and Allergy
  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

@article{f01048f579bb4cc3b8f7964819d99cbb,
title = "Interleukin-6 as an Early Chronic Inflammatory Marker in Polycystic Ovary Syndrome with Insulin Receptor Substrate-2 Polymorphism",
abstract = "Problem Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disorder. This study was to evaluate whether insulin receptor substrate (IRS)-2 Gly1057Asp polymorphism influences chronic inflammatory parameters in Taiwanese patients with PCOS. Method of study DNA was extracted from whole blood samples for genotyping and detection of IRS-2 Gly1057Asp polymorphism in 129 PCOS women and 109 control women. Ninety-seven PCOS women accepted metformin treatment for 3months, and low-grade chronic inflammatory markers were assessed. Results The levels of IL-6 were significantly elevated in PCOS women compared with normal women. Among allelic variant of IRS-2, concentrations of IL-6 were greater in IRS-2 homozygous Asp population. Treatment with metformin significantly reduced IL-6, especially in PCOS patients with IRS-2 homozygous Asp variant. Conclusion The results showed that IL-6 may be an early low-grade chronic inflammatory marker among PCOS patients with IRS-2 polymorphism in Taiwanese population. This pharmacologic study in IRS-2 polymorphism may provide more information for preventing long-term complications in PCOS.",
author = "Lin, {Yue Shan} and Shaw-Jenq Tsai and Lin, {Ming Wei} and Yang, {Cheng Ta} and Huang, {Mei Feng} and Meng-Hsing Wu",
year = "2011",
month = "12",
day = "1",
doi = "10.1111/j.1600-0897.2011.01059.x",
language = "English",
volume = "66",
pages = "527--533",
journal = "American Journal of Reproductive Immunology",
issn = "1046-7408",
publisher = "Wiley-Blackwell",
number = "6",

}

Interleukin-6 as an Early Chronic Inflammatory Marker in Polycystic Ovary Syndrome with Insulin Receptor Substrate-2 Polymorphism. / Lin, Yue Shan; Tsai, Shaw-Jenq; Lin, Ming Wei; Yang, Cheng Ta; Huang, Mei Feng; Wu, Meng-Hsing.

In: American Journal of Reproductive Immunology, Vol. 66, No. 6, 01.12.2011, p. 527-533.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Interleukin-6 as an Early Chronic Inflammatory Marker in Polycystic Ovary Syndrome with Insulin Receptor Substrate-2 Polymorphism

AU - Lin, Yue Shan

AU - Tsai, Shaw-Jenq

AU - Lin, Ming Wei

AU - Yang, Cheng Ta

AU - Huang, Mei Feng

AU - Wu, Meng-Hsing

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Problem Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disorder. This study was to evaluate whether insulin receptor substrate (IRS)-2 Gly1057Asp polymorphism influences chronic inflammatory parameters in Taiwanese patients with PCOS. Method of study DNA was extracted from whole blood samples for genotyping and detection of IRS-2 Gly1057Asp polymorphism in 129 PCOS women and 109 control women. Ninety-seven PCOS women accepted metformin treatment for 3months, and low-grade chronic inflammatory markers were assessed. Results The levels of IL-6 were significantly elevated in PCOS women compared with normal women. Among allelic variant of IRS-2, concentrations of IL-6 were greater in IRS-2 homozygous Asp population. Treatment with metformin significantly reduced IL-6, especially in PCOS patients with IRS-2 homozygous Asp variant. Conclusion The results showed that IL-6 may be an early low-grade chronic inflammatory marker among PCOS patients with IRS-2 polymorphism in Taiwanese population. This pharmacologic study in IRS-2 polymorphism may provide more information for preventing long-term complications in PCOS.

AB - Problem Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disorder. This study was to evaluate whether insulin receptor substrate (IRS)-2 Gly1057Asp polymorphism influences chronic inflammatory parameters in Taiwanese patients with PCOS. Method of study DNA was extracted from whole blood samples for genotyping and detection of IRS-2 Gly1057Asp polymorphism in 129 PCOS women and 109 control women. Ninety-seven PCOS women accepted metformin treatment for 3months, and low-grade chronic inflammatory markers were assessed. Results The levels of IL-6 were significantly elevated in PCOS women compared with normal women. Among allelic variant of IRS-2, concentrations of IL-6 were greater in IRS-2 homozygous Asp population. Treatment with metformin significantly reduced IL-6, especially in PCOS patients with IRS-2 homozygous Asp variant. Conclusion The results showed that IL-6 may be an early low-grade chronic inflammatory marker among PCOS patients with IRS-2 polymorphism in Taiwanese population. This pharmacologic study in IRS-2 polymorphism may provide more information for preventing long-term complications in PCOS.

UR - http://www.scopus.com/inward/record.url?scp=81155131055&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=81155131055&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0897.2011.01059.x

DO - 10.1111/j.1600-0897.2011.01059.x

M3 - Article

C2 - 21801267

AN - SCOPUS:81155131055

VL - 66

SP - 527

EP - 533

JO - American Journal of Reproductive Immunology

JF - American Journal of Reproductive Immunology

SN - 1046-7408

IS - 6

ER -