Intraperitoneal hyperthermia in the management of pseudomyxoma peritonei

Kai Hsi Hsu, Cheng Yang Chou, Yu Chung Chang

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background/Aims: Pseudomyxoma peritonei is a rare disease characterized by diffuse intraperitoneal mucinous tumor and massive mucinous ascites. The mainstay of treatment is surgery in combination with adjuvant therapy. Methodology: From 1995 to 2002, 8 patients with pathologically confirmed pseudomyxoma peritonei were studied. After surgical debulking, intraoperative intraperitoneal hyperthermia was performed followed by 5 days of postoperative intraperitoneal hyperthermia. Normal saline at 46° C was used for hyperthermia. Patients were followed for clinical data, survival, morbidity, and mortality Results: The appendix was the origin of pseudomyxoma peritonei in 6 patients, the ovary in 1 patient, and the fallopian tube in another. The pathologic diagnosis was mucinous adenocarcinoma in 4 patients, mucinous cystadenocarcinoma in 3, and mucinous cystadenoma in 1. Associated morbidity and mortality was 12.5% and 0, respectively. The recurrence rate was 62.5%, with a median follow-up of 52.5 months. The estimated 1-, 3-, and 5-year survival rates were 100%, 88%, and 49%, respectively. Conclusions: Surgical debulking followed by 46 °C normal saline intraperitoneal hyperthermia resulted in a 5-year survival of 49% with low morbidity and no mortality for the treatment of pseudomyxoma peritonei. We concluded that this is an easy, safe, and efficacious treatment for patients with this rare disease.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
Issue number73
Publication statusPublished - 2007 Jan 1

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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