Intrathecal orphenadrine elicits spinal block in the rat

Yu Wen Chen, Jann Inn Tzeng, Yu Chung Chen, Ching-Hsia Hung, Jhi Joung Wang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The purpose of this study was to estimate the local anesthetic effect of orphenadrine, an anti-muscarinic agent, in spinal anesthesia and its comparison with the local anesthetic lidocaine. After the rat was injected intrathecally, the spinal block of orphenadrine and lidocaine was constructed in a dosage-dependent fashion. The potency and duration of spinal anesthesia with orphenadrine were compared with that of lidocaine. Our data demonstrated that orphenadrine and lidocaine elicited dose-dependent spinal blockades on the motor function, sensory, and proprioception. On the 50% effective dose (ED50) basis, the ranks of potency in motor function, nociception, and proprioception were orphenadrine>lidocaine (P<0.01). At equipotent doses (ED25, ED50, ED75), the block duration elicited by orphenadrine was greater than that elicited by lidocaine (P<0.01). Orphenadrine, but not lidocaine, exhibited longer duration of nociceptive/sensory blockade than that of motor blockade at equipotent doses. Ineffective-dose orphenadrine as adjuvant did not enhance spinal anesthesia with lidocaine. The preclinical data revealed that orphenadrine with a more sensory-selective action over motor block exhibited more potent and longer spinal anesthesia when compared to lidocaine.

Original languageEnglish
Pages (from-to)125-130
Number of pages6
JournalEuropean Journal of Pharmacology
Volume742
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Orphenadrine
Lidocaine
Spinal Anesthesia
Proprioception
Local Anesthetics
Nociception
Cholinergic Agents
Anesthetics

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Chen, Yu Wen ; Tzeng, Jann Inn ; Chen, Yu Chung ; Hung, Ching-Hsia ; Wang, Jhi Joung. / Intrathecal orphenadrine elicits spinal block in the rat. In: European Journal of Pharmacology. 2014 ; Vol. 742. pp. 125-130.
@article{e5f935ef5f40416c8255c86d1438fc0f,
title = "Intrathecal orphenadrine elicits spinal block in the rat",
abstract = "The purpose of this study was to estimate the local anesthetic effect of orphenadrine, an anti-muscarinic agent, in spinal anesthesia and its comparison with the local anesthetic lidocaine. After the rat was injected intrathecally, the spinal block of orphenadrine and lidocaine was constructed in a dosage-dependent fashion. The potency and duration of spinal anesthesia with orphenadrine were compared with that of lidocaine. Our data demonstrated that orphenadrine and lidocaine elicited dose-dependent spinal blockades on the motor function, sensory, and proprioception. On the 50{\%} effective dose (ED50) basis, the ranks of potency in motor function, nociception, and proprioception were orphenadrine>lidocaine (P<0.01). At equipotent doses (ED25, ED50, ED75), the block duration elicited by orphenadrine was greater than that elicited by lidocaine (P<0.01). Orphenadrine, but not lidocaine, exhibited longer duration of nociceptive/sensory blockade than that of motor blockade at equipotent doses. Ineffective-dose orphenadrine as adjuvant did not enhance spinal anesthesia with lidocaine. The preclinical data revealed that orphenadrine with a more sensory-selective action over motor block exhibited more potent and longer spinal anesthesia when compared to lidocaine.",
author = "Chen, {Yu Wen} and Tzeng, {Jann Inn} and Chen, {Yu Chung} and Ching-Hsia Hung and Wang, {Jhi Joung}",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.ejphar.2014.08.035",
language = "English",
volume = "742",
pages = "125--130",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",

}

Intrathecal orphenadrine elicits spinal block in the rat. / Chen, Yu Wen; Tzeng, Jann Inn; Chen, Yu Chung; Hung, Ching-Hsia; Wang, Jhi Joung.

In: European Journal of Pharmacology, Vol. 742, 01.01.2014, p. 125-130.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Intrathecal orphenadrine elicits spinal block in the rat

AU - Chen, Yu Wen

AU - Tzeng, Jann Inn

AU - Chen, Yu Chung

AU - Hung, Ching-Hsia

AU - Wang, Jhi Joung

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The purpose of this study was to estimate the local anesthetic effect of orphenadrine, an anti-muscarinic agent, in spinal anesthesia and its comparison with the local anesthetic lidocaine. After the rat was injected intrathecally, the spinal block of orphenadrine and lidocaine was constructed in a dosage-dependent fashion. The potency and duration of spinal anesthesia with orphenadrine were compared with that of lidocaine. Our data demonstrated that orphenadrine and lidocaine elicited dose-dependent spinal blockades on the motor function, sensory, and proprioception. On the 50% effective dose (ED50) basis, the ranks of potency in motor function, nociception, and proprioception were orphenadrine>lidocaine (P<0.01). At equipotent doses (ED25, ED50, ED75), the block duration elicited by orphenadrine was greater than that elicited by lidocaine (P<0.01). Orphenadrine, but not lidocaine, exhibited longer duration of nociceptive/sensory blockade than that of motor blockade at equipotent doses. Ineffective-dose orphenadrine as adjuvant did not enhance spinal anesthesia with lidocaine. The preclinical data revealed that orphenadrine with a more sensory-selective action over motor block exhibited more potent and longer spinal anesthesia when compared to lidocaine.

AB - The purpose of this study was to estimate the local anesthetic effect of orphenadrine, an anti-muscarinic agent, in spinal anesthesia and its comparison with the local anesthetic lidocaine. After the rat was injected intrathecally, the spinal block of orphenadrine and lidocaine was constructed in a dosage-dependent fashion. The potency and duration of spinal anesthesia with orphenadrine were compared with that of lidocaine. Our data demonstrated that orphenadrine and lidocaine elicited dose-dependent spinal blockades on the motor function, sensory, and proprioception. On the 50% effective dose (ED50) basis, the ranks of potency in motor function, nociception, and proprioception were orphenadrine>lidocaine (P<0.01). At equipotent doses (ED25, ED50, ED75), the block duration elicited by orphenadrine was greater than that elicited by lidocaine (P<0.01). Orphenadrine, but not lidocaine, exhibited longer duration of nociceptive/sensory blockade than that of motor blockade at equipotent doses. Ineffective-dose orphenadrine as adjuvant did not enhance spinal anesthesia with lidocaine. The preclinical data revealed that orphenadrine with a more sensory-selective action over motor block exhibited more potent and longer spinal anesthesia when compared to lidocaine.

UR - http://www.scopus.com/inward/record.url?scp=84923686858&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923686858&partnerID=8YFLogxK

U2 - 10.1016/j.ejphar.2014.08.035

DO - 10.1016/j.ejphar.2014.08.035

M3 - Article

VL - 742

SP - 125

EP - 130

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

ER -