TY - JOUR
T1 - Intrathecal pramipexole and selegiline for sensory and motor block in rats
AU - Yeh, Chun Chang
AU - Chiu, Chong Chi
AU - Wang, Jhi Joung
AU - Chou, An Kuo
AU - Chen, Yu Wen
AU - Zhu, Guan Cheng
AU - Hung, Ching Hsia
N1 - Funding Information:
The authors gratefully acknowledge the financial support provided by the grant (MOST 110-2314-B-039-014-MY3; MOST 109-2918-I-039-001) from the Ministry of Science and Technology (Taiwan) and by the grant (CMU110-MF-110) from the China Medical University (Taiwan).
Publisher Copyright:
© 2022, The Author(s) under exclusive licence to Maj Institute of Pharmacology Polish Academy of Sciences.
PY - 2022/6
Y1 - 2022/6
N2 - Background: The purpose of the study was to investigate spinal sensory and motor block by antiparkinsonian drugs (pramipexole and selegiline), and the combination of pramipexole and the local anesthetic lidocaine. Methods: Using a technique of spinal blockade in rats, the effects of pramipexole, selegiline, and coadministration of pramipexole and lidocaine on spinal blockades of motor and sensory function were investigated. Results: Under a concentration of 100 mM, pramipexole displayed more potent and had a longer duration of nociceptive, proprioceptive, and motor block than selegiline, whereas pramipexole and selegiline were less potent in comparison to lidocaine. Pramipexole produced spinal nociceptive, proprioceptive, and motor blocks in a dose-related manner. On the ED50 (50% effective dose) basis, the rank-order potency on nociceptive, proprioceptive, and motor block was pramipexole < lidocaine. The spinal block duration of pramipexole was greater than lidocaine at every equipotent dose tested (ED25, ED50, and ED75). Coadministration of lidocaine (ED50 or ED95) with pramipexole (4.5 μmol/kg) improved the effect (efficacy) and duration of the spinal block. Conclusions: Pramipexole and selegiline were less potent than lidocaine to block sensory and motor responses. The duration of the spinal anesthetic effect of pramipexole was longer than lidocaine. At a non-effective dose, pramipexole increased the duration of efficacy of lidocaine.
AB - Background: The purpose of the study was to investigate spinal sensory and motor block by antiparkinsonian drugs (pramipexole and selegiline), and the combination of pramipexole and the local anesthetic lidocaine. Methods: Using a technique of spinal blockade in rats, the effects of pramipexole, selegiline, and coadministration of pramipexole and lidocaine on spinal blockades of motor and sensory function were investigated. Results: Under a concentration of 100 mM, pramipexole displayed more potent and had a longer duration of nociceptive, proprioceptive, and motor block than selegiline, whereas pramipexole and selegiline were less potent in comparison to lidocaine. Pramipexole produced spinal nociceptive, proprioceptive, and motor blocks in a dose-related manner. On the ED50 (50% effective dose) basis, the rank-order potency on nociceptive, proprioceptive, and motor block was pramipexole < lidocaine. The spinal block duration of pramipexole was greater than lidocaine at every equipotent dose tested (ED25, ED50, and ED75). Coadministration of lidocaine (ED50 or ED95) with pramipexole (4.5 μmol/kg) improved the effect (efficacy) and duration of the spinal block. Conclusions: Pramipexole and selegiline were less potent than lidocaine to block sensory and motor responses. The duration of the spinal anesthetic effect of pramipexole was longer than lidocaine. At a non-effective dose, pramipexole increased the duration of efficacy of lidocaine.
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U2 - 10.1007/s43440-022-00368-x
DO - 10.1007/s43440-022-00368-x
M3 - Article
C2 - 35554880
AN - SCOPUS:85130651955
SN - 1734-1140
VL - 74
SP - 470
EP - 480
JO - Pharmacological Reports
JF - Pharmacological Reports
IS - 3
ER -