Intrathecal pramoxine causes long-lasting spinal sensory and motor block in rats

An Kuo Chou, Chong Chi Chiu, Ming Ming Han, Yu Wen Chen, Jhi Joung Wang, Ching Hsia Hung

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: The objective of this experiment was to investigate spinal anaesthetic effects of pramoxine and its comparison with bupivacaine, a long-lasting local anaesthetic. Methods: After intrathecal injection, three neurobehavioural assessments, which consisted of nociceptive, proprioceptive and motor block, were constructed in rats. The effects of bupivacaine and pramoxine (four doses of each drug) in a dose-related manner were conducted to obtain the ED50 (50% effective dose). Pramoxine potency and duration at provoking spinal nociceptive, proprioceptive and motor block were compared with those of bupivacaine. Key findings: We manifested that pramoxine provoked dose-relatedly spinal blockades of nociception, proprioception and motor function. Based on the ED50, the rank potency at producing spinal nociceptive, proprioceptive and motor block was bupivacaine (0.90 (0.82–1.02), 1.00 (0.92–1.08) and 1.16 (1.02–1.34) μmol/kg) greater (P < 0.01 for the differences) than pramoxine (15.47 (14.04–17.05), 16.46 (15.06–17.99), and 17.77 (16.48–19.15) μmol/kg). The spinal block duration created by bupivacaine was not predominantly different (P > 0.05 for the differences) from that created by pramoxine at the equipotent doses (ED75, ED50 and ED25). Conclusions: Our preclinical experiment indicated that pramoxine elicited a dose-related spinal block, was less potent than bupivacaine and had a similar duration of spinal block compared with bupivacaine.

Original languageEnglish
Pages (from-to)543-549
Number of pages7
JournalJournal of Pharmacy and Pharmacology
Volume70
Issue number4
DOIs
Publication statusPublished - 2018 Apr

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this