TY - JOUR
T1 - Intrathecal rimantadine induces motor, proprioceptive, and nociceptive blockades in rats
AU - Tzeng, Jann Inn
AU - Wang, Jieh Neng
AU - Wang, Jhi Joung
AU - Chen, Yu Wen
AU - Hung, Ching Hsia
N1 - Funding Information:
The financial support provided for the study by the grant (CMNCKU10412) from the Chi-Mei Medical Center, Taiwan .
Publisher Copyright:
© 2016 Elsevier Ireland Ltd.
PY - 2016/4/8
Y1 - 2016/4/8
N2 - The purpose of the experiment was to evaluate the local anesthetic effect of rimantadine in spinal anesthesia. Rimantadine in a dose-dependent fashion was constructed after intrathecally injecting the rats with four different doses. The potency and duration of rimantadine were compared with that of the local anesthetic lidocaine at producing spinal motor, nociceptive, and proprioceptive blockades. We demonstrated that intrathecal rimantadine dose-dependently produced spinal motor, nociceptive, and proprioceptive blockades. On the 50% effective dose (ED50) basis, the ranks of potencies at inducing spinal motor, nociceptive, and proprioceptive blockades was lidocaine > rimantadine (P < 0.01). Rimantadine exhibited more nociceptive block (ED50) than motor block (P < 0.05). At equi-anesthetic doses (ED25, ED50, and ED75), the spinal block duration produced by rimantadine was longer than that produced by lidocaine (P < 0.01). Furthermore, rimantadine (26.52 μmol/kg) prolonged the nociceptive nerve block more than the motor block (P < 0.001). Our preclinical data showed that rimantadine, with a more sensory-selective action over motor block, was less potent than lidocaine. Rimantadine produced longer duration in spinal anesthesia when compared with lidocaine.
AB - The purpose of the experiment was to evaluate the local anesthetic effect of rimantadine in spinal anesthesia. Rimantadine in a dose-dependent fashion was constructed after intrathecally injecting the rats with four different doses. The potency and duration of rimantadine were compared with that of the local anesthetic lidocaine at producing spinal motor, nociceptive, and proprioceptive blockades. We demonstrated that intrathecal rimantadine dose-dependently produced spinal motor, nociceptive, and proprioceptive blockades. On the 50% effective dose (ED50) basis, the ranks of potencies at inducing spinal motor, nociceptive, and proprioceptive blockades was lidocaine > rimantadine (P < 0.01). Rimantadine exhibited more nociceptive block (ED50) than motor block (P < 0.05). At equi-anesthetic doses (ED25, ED50, and ED75), the spinal block duration produced by rimantadine was longer than that produced by lidocaine (P < 0.01). Furthermore, rimantadine (26.52 μmol/kg) prolonged the nociceptive nerve block more than the motor block (P < 0.001). Our preclinical data showed that rimantadine, with a more sensory-selective action over motor block, was less potent than lidocaine. Rimantadine produced longer duration in spinal anesthesia when compared with lidocaine.
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U2 - 10.1016/j.neulet.2016.02.061
DO - 10.1016/j.neulet.2016.02.061
M3 - Article
C2 - 26949181
AN - SCOPUS:84960344845
SN - 0304-3940
VL - 618
SP - 94
EP - 98
JO - Neuroscience Letters
JF - Neuroscience Letters
ER -