TY - JOUR
T1 - Involvement of nitric oxide in gastric protection of epinephrine in endotoxin intoxication in rats
AU - Hsu, Dur Zong
AU - Liu, Ming Yie
N1 - Funding Information:
This research was supported by grants DOH92-TD-1009 from the Department of Health of Taiwan and NSC91-2314-B154 from National Science Council of Taiwan. We thank P.-J. Chiang for doing the animal experiments.
PY - 2004/11/15
Y1 - 2004/11/15
N2 - Reduction in blood pressure may cause gastric mucosal hypoxia and injury during endotoxin intoxication. Epinephrine is found to increase gastric mucosal perfusion while managing hypotension. Nitric oxide plays an important role in regulating gastric mucosal perfusion and maintaining gastric integrity. The aim of this study was to investigate the involvement of nitric oxide in the gastric protection of epinephrine by determining gastric mucosal lipid peroxidation, ulceration, and hemorrhage levels in endotoxin intoxication in rats. Epinephrine significantly increased gastric mucosal nitrite levels, decreased gastric mucosal lipid peroxidation levels, and ameliorated gastric ulceration and hemorrhage in endotoxin-treated rats. Furthermore, nitric oxide synthase inhibitors potently reversed the effects of epinephrine on gastric mucosa in endotoxin-treated rats. It was suggested that nitric oxide might be involved in the protective effect of epinephrine on gastric mucosal injury in endotoxin intoxication in rats.
AB - Reduction in blood pressure may cause gastric mucosal hypoxia and injury during endotoxin intoxication. Epinephrine is found to increase gastric mucosal perfusion while managing hypotension. Nitric oxide plays an important role in regulating gastric mucosal perfusion and maintaining gastric integrity. The aim of this study was to investigate the involvement of nitric oxide in the gastric protection of epinephrine by determining gastric mucosal lipid peroxidation, ulceration, and hemorrhage levels in endotoxin intoxication in rats. Epinephrine significantly increased gastric mucosal nitrite levels, decreased gastric mucosal lipid peroxidation levels, and ameliorated gastric ulceration and hemorrhage in endotoxin-treated rats. Furthermore, nitric oxide synthase inhibitors potently reversed the effects of epinephrine on gastric mucosa in endotoxin-treated rats. It was suggested that nitric oxide might be involved in the protective effect of epinephrine on gastric mucosal injury in endotoxin intoxication in rats.
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U2 - 10.1016/j.tox.2004.06.059
DO - 10.1016/j.tox.2004.06.059
M3 - Article
C2 - 15388246
AN - SCOPUS:4544327670
SN - 0300-483X
VL - 204
SP - 203
EP - 208
JO - Toxicology
JF - Toxicology
IS - 2-3
ER -