Iron oxide nanoparticles for targeted cancer imaging and diagnostics

Joshua E. Rosen, Lorena Chan, Dar-Bin Shieh, Frank X. Gu

Research output: Contribution to journalReview article

228 Citations (Scopus)

Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs) have proven to be highly effective contrast agents for the magnetic resonance imaging diagnosis of solid tumors. This review examines the various techniques that are available to selectively target SPIONs toward a wide variety of cancerous tissues, with specific attention given to how the surface properties imparted by various targeting ligands affect the particles tissue distribution and pharmacokinetics. An in-depth examination of the various human cell lines utilized to test the assorted targeting methods is also presented, as well as an overview of the various types of cancer against which each targeting method has been utilized for both in vivo and in vitro studies. From the Clinical Editor: Functionalized superparamagnetic iron oxide nanoparticles (SPIONs) are very potent negative contrast materials for magnetic resonance imaging-based diagnosis. This comprehensive review examines techniques that selectively target SPIONs toward a wide variety of malignancies.

Original languageEnglish
Pages (from-to)275-290
Number of pages16
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume8
Issue number3
DOIs
Publication statusPublished - 2012 Apr 1

Fingerprint

Diagnostic Imaging
Iron oxides
Nanoparticles
Imaging techniques
Magnetic resonance
Contrast Media
Neoplasms
Magnetic Resonance Imaging
Tissue
Pharmacokinetics
Surface Properties
Tissue Distribution
Surface properties
Tumors
Ligands
Cells
Cell Line
ferric oxide

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

Cite this

Rosen, Joshua E. ; Chan, Lorena ; Shieh, Dar-Bin ; Gu, Frank X. / Iron oxide nanoparticles for targeted cancer imaging and diagnostics. In: Nanomedicine: Nanotechnology, Biology, and Medicine. 2012 ; Vol. 8, No. 3. pp. 275-290.
@article{02fc655828954a7e866f287a73ff8c29,
title = "Iron oxide nanoparticles for targeted cancer imaging and diagnostics",
abstract = "Superparamagnetic iron oxide nanoparticles (SPIONs) have proven to be highly effective contrast agents for the magnetic resonance imaging diagnosis of solid tumors. This review examines the various techniques that are available to selectively target SPIONs toward a wide variety of cancerous tissues, with specific attention given to how the surface properties imparted by various targeting ligands affect the particles tissue distribution and pharmacokinetics. An in-depth examination of the various human cell lines utilized to test the assorted targeting methods is also presented, as well as an overview of the various types of cancer against which each targeting method has been utilized for both in vivo and in vitro studies. From the Clinical Editor: Functionalized superparamagnetic iron oxide nanoparticles (SPIONs) are very potent negative contrast materials for magnetic resonance imaging-based diagnosis. This comprehensive review examines techniques that selectively target SPIONs toward a wide variety of malignancies.",
author = "Rosen, {Joshua E.} and Lorena Chan and Dar-Bin Shieh and Gu, {Frank X.}",
year = "2012",
month = "4",
day = "1",
doi = "10.1016/j.nano.2011.08.017",
language = "English",
volume = "8",
pages = "275--290",
journal = "Nanomedicine: Nanotechnology, Biology, and Medicine",
issn = "1549-9634",
publisher = "Elsevier Inc.",
number = "3",

}

Iron oxide nanoparticles for targeted cancer imaging and diagnostics. / Rosen, Joshua E.; Chan, Lorena; Shieh, Dar-Bin; Gu, Frank X.

In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 8, No. 3, 01.04.2012, p. 275-290.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Iron oxide nanoparticles for targeted cancer imaging and diagnostics

AU - Rosen, Joshua E.

AU - Chan, Lorena

AU - Shieh, Dar-Bin

AU - Gu, Frank X.

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Superparamagnetic iron oxide nanoparticles (SPIONs) have proven to be highly effective contrast agents for the magnetic resonance imaging diagnosis of solid tumors. This review examines the various techniques that are available to selectively target SPIONs toward a wide variety of cancerous tissues, with specific attention given to how the surface properties imparted by various targeting ligands affect the particles tissue distribution and pharmacokinetics. An in-depth examination of the various human cell lines utilized to test the assorted targeting methods is also presented, as well as an overview of the various types of cancer against which each targeting method has been utilized for both in vivo and in vitro studies. From the Clinical Editor: Functionalized superparamagnetic iron oxide nanoparticles (SPIONs) are very potent negative contrast materials for magnetic resonance imaging-based diagnosis. This comprehensive review examines techniques that selectively target SPIONs toward a wide variety of malignancies.

AB - Superparamagnetic iron oxide nanoparticles (SPIONs) have proven to be highly effective contrast agents for the magnetic resonance imaging diagnosis of solid tumors. This review examines the various techniques that are available to selectively target SPIONs toward a wide variety of cancerous tissues, with specific attention given to how the surface properties imparted by various targeting ligands affect the particles tissue distribution and pharmacokinetics. An in-depth examination of the various human cell lines utilized to test the assorted targeting methods is also presented, as well as an overview of the various types of cancer against which each targeting method has been utilized for both in vivo and in vitro studies. From the Clinical Editor: Functionalized superparamagnetic iron oxide nanoparticles (SPIONs) are very potent negative contrast materials for magnetic resonance imaging-based diagnosis. This comprehensive review examines techniques that selectively target SPIONs toward a wide variety of malignancies.

UR - http://www.scopus.com/inward/record.url?scp=84858615014&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858615014&partnerID=8YFLogxK

U2 - 10.1016/j.nano.2011.08.017

DO - 10.1016/j.nano.2011.08.017

M3 - Review article

C2 - 21930108

AN - SCOPUS:84858615014

VL - 8

SP - 275

EP - 290

JO - Nanomedicine: Nanotechnology, Biology, and Medicine

JF - Nanomedicine: Nanotechnology, Biology, and Medicine

SN - 1549-9634

IS - 3

ER -