Is there different risk of cancer among end-stage renal disease patients undergoing hemodialysis and peritoneal dialysis?

Yi Che Lee, Shih Yuan Hung, Hao Kuang Wang, Chi Wei Lin, Hsi Hao Wang, Min Yu Chang, Junne-Ming Sung, Yuan-Yow Chiou, Sheng-Hsiang Lin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cancer is a global issue in recent decade. Despite this alarming increase in the incidence of cancer, to date, whether the risk of developing cancer differs among peritoneal dialysis (PD) and hemodialysis (HD) patients is still uncertain. In this retrospective cohort study, data were obtained from the National Health Insurance Research Database of Taiwan, which provides coverage to almost 99% of the nation's population. After matching, a total of 4491 (or 3369) incident PD patients and 8982 (or 6738) incident HD patients between 2000 and 2009 were enrolled from the database. In addition, 22,455 (or 16,845) nondialysis patients were selected as a control group. The patients were monitored for the occurrence of cancer until 2010, and their data were analyzed using several different models. In general, the results showed that the risks of hepatocellular, kidney, bladder, extra kidney/bladder urinary tract, and thyroid cancers were higher in dialysis patients. We also compared the risk of cancer between two dialysis groups by using the HD patients as the reference group. The result showed that there is no significant different for each cancer risk between two dialysis groups. In conclusion, dialysis patients had a higher risk of certain types of cancer than those in the nonuremia group. However, there was no significant difference in the cancer risk between the two dialysis groups when compared directly.

Original languageEnglish
Pages (from-to)485-498
Number of pages14
JournalCancer medicine
Volume7
Issue number2
DOIs
Publication statusPublished - 2018 Feb 1

Fingerprint

Peritoneal Dialysis
Chronic Kidney Failure
Renal Dialysis
Dialysis
Neoplasms
Databases
Urologic Neoplasms
Kidney
National Health Programs
Taiwan
Thyroid Neoplasms
Urinary Bladder Neoplasms
Urinary Bladder
Cohort Studies
Retrospective Studies
Control Groups
Incidence
Research
Population

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Lee, Yi Che ; Hung, Shih Yuan ; Wang, Hao Kuang ; Lin, Chi Wei ; Wang, Hsi Hao ; Chang, Min Yu ; Sung, Junne-Ming ; Chiou, Yuan-Yow ; Lin, Sheng-Hsiang. / Is there different risk of cancer among end-stage renal disease patients undergoing hemodialysis and peritoneal dialysis?. In: Cancer medicine. 2018 ; Vol. 7, No. 2. pp. 485-498.
@article{c0a11318342c44a295a60ac38e348155,
title = "Is there different risk of cancer among end-stage renal disease patients undergoing hemodialysis and peritoneal dialysis?",
abstract = "Cancer is a global issue in recent decade. Despite this alarming increase in the incidence of cancer, to date, whether the risk of developing cancer differs among peritoneal dialysis (PD) and hemodialysis (HD) patients is still uncertain. In this retrospective cohort study, data were obtained from the National Health Insurance Research Database of Taiwan, which provides coverage to almost 99{\%} of the nation's population. After matching, a total of 4491 (or 3369) incident PD patients and 8982 (or 6738) incident HD patients between 2000 and 2009 were enrolled from the database. In addition, 22,455 (or 16,845) nondialysis patients were selected as a control group. The patients were monitored for the occurrence of cancer until 2010, and their data were analyzed using several different models. In general, the results showed that the risks of hepatocellular, kidney, bladder, extra kidney/bladder urinary tract, and thyroid cancers were higher in dialysis patients. We also compared the risk of cancer between two dialysis groups by using the HD patients as the reference group. The result showed that there is no significant different for each cancer risk between two dialysis groups. In conclusion, dialysis patients had a higher risk of certain types of cancer than those in the nonuremia group. However, there was no significant difference in the cancer risk between the two dialysis groups when compared directly.",
author = "Lee, {Yi Che} and Hung, {Shih Yuan} and Wang, {Hao Kuang} and Lin, {Chi Wei} and Wang, {Hsi Hao} and Chang, {Min Yu} and Junne-Ming Sung and Yuan-Yow Chiou and Sheng-Hsiang Lin",
year = "2018",
month = "2",
day = "1",
doi = "10.1002/cam4.1289",
language = "English",
volume = "7",
pages = "485--498",
journal = "Cancer Medicine",
issn = "2045-7634",
publisher = "John Wiley and Sons Ltd",
number = "2",

}

Is there different risk of cancer among end-stage renal disease patients undergoing hemodialysis and peritoneal dialysis? / Lee, Yi Che; Hung, Shih Yuan; Wang, Hao Kuang; Lin, Chi Wei; Wang, Hsi Hao; Chang, Min Yu; Sung, Junne-Ming; Chiou, Yuan-Yow; Lin, Sheng-Hsiang.

In: Cancer medicine, Vol. 7, No. 2, 01.02.2018, p. 485-498.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Is there different risk of cancer among end-stage renal disease patients undergoing hemodialysis and peritoneal dialysis?

AU - Lee, Yi Che

AU - Hung, Shih Yuan

AU - Wang, Hao Kuang

AU - Lin, Chi Wei

AU - Wang, Hsi Hao

AU - Chang, Min Yu

AU - Sung, Junne-Ming

AU - Chiou, Yuan-Yow

AU - Lin, Sheng-Hsiang

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Cancer is a global issue in recent decade. Despite this alarming increase in the incidence of cancer, to date, whether the risk of developing cancer differs among peritoneal dialysis (PD) and hemodialysis (HD) patients is still uncertain. In this retrospective cohort study, data were obtained from the National Health Insurance Research Database of Taiwan, which provides coverage to almost 99% of the nation's population. After matching, a total of 4491 (or 3369) incident PD patients and 8982 (or 6738) incident HD patients between 2000 and 2009 were enrolled from the database. In addition, 22,455 (or 16,845) nondialysis patients were selected as a control group. The patients were monitored for the occurrence of cancer until 2010, and their data were analyzed using several different models. In general, the results showed that the risks of hepatocellular, kidney, bladder, extra kidney/bladder urinary tract, and thyroid cancers were higher in dialysis patients. We also compared the risk of cancer between two dialysis groups by using the HD patients as the reference group. The result showed that there is no significant different for each cancer risk between two dialysis groups. In conclusion, dialysis patients had a higher risk of certain types of cancer than those in the nonuremia group. However, there was no significant difference in the cancer risk between the two dialysis groups when compared directly.

AB - Cancer is a global issue in recent decade. Despite this alarming increase in the incidence of cancer, to date, whether the risk of developing cancer differs among peritoneal dialysis (PD) and hemodialysis (HD) patients is still uncertain. In this retrospective cohort study, data were obtained from the National Health Insurance Research Database of Taiwan, which provides coverage to almost 99% of the nation's population. After matching, a total of 4491 (or 3369) incident PD patients and 8982 (or 6738) incident HD patients between 2000 and 2009 were enrolled from the database. In addition, 22,455 (or 16,845) nondialysis patients were selected as a control group. The patients were monitored for the occurrence of cancer until 2010, and their data were analyzed using several different models. In general, the results showed that the risks of hepatocellular, kidney, bladder, extra kidney/bladder urinary tract, and thyroid cancers were higher in dialysis patients. We also compared the risk of cancer between two dialysis groups by using the HD patients as the reference group. The result showed that there is no significant different for each cancer risk between two dialysis groups. In conclusion, dialysis patients had a higher risk of certain types of cancer than those in the nonuremia group. However, there was no significant difference in the cancer risk between the two dialysis groups when compared directly.

UR - http://www.scopus.com/inward/record.url?scp=85040788136&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040788136&partnerID=8YFLogxK

U2 - 10.1002/cam4.1289

DO - 10.1002/cam4.1289

M3 - Article

VL - 7

SP - 485

EP - 498

JO - Cancer Medicine

JF - Cancer Medicine

SN - 2045-7634

IS - 2

ER -