Isolation and identification of antiplatelet aggregatory principles from the leaves of Piper lolot

Chia Ying Li, Wei Jern Tsai, Amooru Gangaiah Damu, E. Jian Lee, Tian Shung Wu, Xuan Dung Nguyen, Dinh Thang Tran, Le Thanh

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24 Citations (Scopus)

Abstract

The methanolic extract of Piper lolot, having shown potent inhibitory activity on platelet aggregation induced by arachidonic acid (AA) and platelet activating factor (PAF), was subjected to activity-guided isolation to yield twelve new amide alkaloids, piperlotine A-L (1-12), along with twenty-nine known compounds. Their structures were elucidated on the basis of spectroscopic analysis. The isolated compounds were tested for their inhibitory activity on the rabbit platelet aggregation. The compounds piperlotine A (1), piperlotine C (3), piperlotine D (4), piperlotine E (5), 3-phenyl-1-(2,4,6-trihydroxyphenyl) propan-1-one (21), 3-(4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one (22), 1-trans-cinnamoylpyrrolidine (24), sarmentine (26), pellitorine (27), methyl 3-phenylpropionate (32), and (10S)-10-hydroxypheophorbide a methyl ester (40) showed potent antiplatelet aggregation activity.

Original languageEnglish
Pages (from-to)9436-9442
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Volume55
Issue number23
DOIs
Publication statusPublished - 2007 Nov 14

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

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