Isolation of tumor cells using a new microfluidic incubator with moving-wall structures

Ying Hsin Chuang, Lien Yu Hung, Keng-Fu Hsu, Cheng-Yang Chou, Gwo Bin Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Isolation and detection of tumor cells (TCs) from a large amount of biological samples have been a major challenge in clinical diagnosis. To tackle this problem, a three-dimensional micro incubator using deflecting membranes has been reported by our group previously. However, it requires a relatively complicated fabrication process, which involves bonding of multiple polydimethyl siloxane (PDMS) layers. In this study, a new micro incubator equipped with moving-wall structures is presented. Compared with our previous work, the new chip requires a simpler fabrication process and can be activated with ease. Experimental results showed that the developed micro incubator can be used for isolation of tumor cells when incorporated with magnetic beads. Furthermore, counting and detection of these cancer cells can be further performed when integrated with a micro flow cytometer and a micro nucleic acid module. Therefore, the developed device may be promising for further biomedical applications.

Original languageEnglish
Title of host publication2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
Pages1931-1934
Number of pages4
DOIs
Publication statusPublished - 2011
Event2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 - Beijing, China
Duration: 2011 Jun 52011 Jun 9

Other

Other2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
CountryChina
CityBeijing
Period11-06-0511-06-09

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All Science Journal Classification (ASJC) codes

  • Hardware and Architecture
  • Electrical and Electronic Engineering

Cite this

Chuang, Y. H., Hung, L. Y., Hsu, K-F., Chou, C-Y., & Lee, G. B. (2011). Isolation of tumor cells using a new microfluidic incubator with moving-wall structures. In 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 (pp. 1931-1934). [5969373] https://doi.org/10.1109/TRANSDUCERS.2011.5969373