Isolation, structure elucidation, and syntheses of isoneocryptotanshinone II and tanshinlactone a from Salvia miltiorrhiza

Chang Ming Sun, Tsung Mei Chin, Yun Lian Lin, Chien Jui Chen, Wei Chou Chen, Tian Shung Wu, Ming Jaw Don

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Two new components, isoneocryptotanshinone II (1) and tanshinlactone A (2), were isolated from an EtOH extract of Salvia miltiorrhiza. The structures of 1 and 2 were established by spectroscopic methods and total syntheses. Compound (2) exhibited moderate cytotoxic activities with a CD50 range of 6.87-8.85 μg/mL against the HeLa (cervical epitheloid carcinoma), HepG2 (hepatocellular carcinoma) and OVCAR-3 (ovarian adenocarcinoma) cell lines.

Original languageEnglish
Pages (from-to)247-255
Number of pages9
JournalHeterocycles
Volume68
Issue number2
Publication statusPublished - 2006 Feb 1

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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