Isolation, structure elucidation, and syntheses of isoneocryptotanshinone II and tanshinlactone a from Salvia miltiorrhiza

Chang Ming Sun; Tsung Mei Chin; Yun Lian Lin; Chien Jui Chen; Wei Chou Chen; Tian Shung Wu; Ming Jaw Don

doi:10.3987/com-05-10591

Isolation, structure elucidation, and syntheses of isoneocryptotanshinone II and tanshinlactone a from Salvia miltiorrhiza

Chang Ming Sun, Tsung Mei Chin, Yun Lian Lin, Chien Jui Chen, Wei Chou Chen, Tian Shung Wu, Ming Jaw Don

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Two new components, isoneocryptotanshinone II (1) and tanshinlactone A (2), were isolated from an EtOH extract of Salvia miltiorrhiza. The structures of 1 and 2 were established by spectroscopic methods and total syntheses. Compound (2) exhibited moderate cytotoxic activities with a CD₅₀ range of 6.87-8.85 μg/mL against the HeLa (cervical epitheloid carcinoma), HepG2 (hepatocellular carcinoma) and OVCAR-3 (ovarian adenocarcinoma) cell lines.

Original language	English
Pages (from-to)	247-255
Number of pages	9
Journal	Heterocycles
Volume	68
Issue number	2
DOIs	https://doi.org/10.3987/com-05-10591
Publication status	Published - 2006 Feb 1

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Pharmacology
Organic Chemistry

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abstract = "Two new components, isoneocryptotanshinone II (1) and tanshinlactone A (2), were isolated from an EtOH extract of Salvia miltiorrhiza. The structures of 1 and 2 were established by spectroscopic methods and total syntheses. Compound (2) exhibited moderate cytotoxic activities with a CD50 range of 6.87-8.85 μg/mL against the HeLa (cervical epitheloid carcinoma), HepG2 (hepatocellular carcinoma) and OVCAR-3 (ovarian adenocarcinoma) cell lines.",

author = "Sun, {Chang Ming} and Chin, {Tsung Mei} and Lin, {Yun Lian} and Chen, {Chien Jui} and Chen, {Wei Chou} and Wu, {Tian Shung} and Don, {Ming Jaw}",

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AU - Sun, Chang Ming

AU - Chin, Tsung Mei

AU - Lin, Yun Lian

AU - Chen, Chien Jui

AU - Chen, Wei Chou

AU - Wu, Tian Shung

AU - Don, Ming Jaw

PY - 2006/2/1

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AB - Two new components, isoneocryptotanshinone II (1) and tanshinlactone A (2), were isolated from an EtOH extract of Salvia miltiorrhiza. The structures of 1 and 2 were established by spectroscopic methods and total syntheses. Compound (2) exhibited moderate cytotoxic activities with a CD50 range of 6.87-8.85 μg/mL against the HeLa (cervical epitheloid carcinoma), HepG2 (hepatocellular carcinoma) and OVCAR-3 (ovarian adenocarcinoma) cell lines.

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Isolation, structure elucidation, and syntheses of isoneocryptotanshinone II and tanshinlactone a from Salvia miltiorrhiza

Abstract

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