Jarisch-Herxheimer reaction after penicillin therapy among patients with syphilis in the era of the HIV infection epidemic: Incidence and risk factors

Chia Jui Yang, Nan Yao Lee, Yu Hui Lin, Hsin Chun Lee, Wen Chien Ko, Chun Hsing Liao, Cheng Hsin Wu, Chia Ying Hsieh, Pei Ying Wu, Wen Chun Liu, Ya Chu Chang, Chien Ching Hung

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31 Citations (Scopus)

Abstract

The incidence of and risk factors for Jarisch-Herxheimer (JH) reaction were investigated prospectively among 240 human immunodeficiency virus (HIV)-infected and 115 HIV-uninfected patients with syphilis who received penicillin treatment. The overall rate of JH reaction was 31.5% (34.6% in HIV-infected patients and 25.2% in HIV-uninfected patients). In multivariate analysis, risk factors for JH reaction included high rapid plasma reagin (RPR) titers (per log2 RPR increase, risk ratio [RR], 1.19; 95% confidence interval [CI], 1.04-1.37), early syphilis (RR, 8.59; 95% CI, 4.75-15.56), and prior penicillin treatment (RR, 0.39; 95% CI, 0.20-0.78).

Original languageEnglish
Pages (from-to)976-979
Number of pages4
JournalClinical Infectious Diseases
Volume51
Issue number8
DOIs
Publication statusPublished - 2010 Oct 15

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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