Judicious use of transthoracic echocardiography in infective endocarditis screening

Yen-Wen Liu, Wei-Chuan Tsai, Chin-Hsin Hsu, Li Jen Lin, Wei-Ting Lee, Chun Hsiu Chen, Jyh Hong Chen

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

BACKGROUND: Patients with a very low probability of infective endocarditis (IE) do not benefit from transthoracic echocardiography (TTE). Because the term 'very low probability' has not yet been defined, the present prospective study sought to identify the population with a 'very low probability'. METHODS: TTE was performed between July 2005 and October 2006 in consecutive patients clinically suspected of having IE. Clinical parameters suggestive of IE and presence of infectious focus were recorded. RESULTS: Twenty-four (15.5%) of 155 patients studied had positive findings on TTE. Significant positive predictors were embolic events, intravenous drug use, the presence of a prosthetic valve, positive blood cultures and immunological phenomena. The significant negative predictor was confirmed infection sites other than endocardium. Sixty-three (40.6%) of 155 patients without positive predictors were found to have no vegetation. Thus, the collective absence of these predictors indicated a zero probability of TTE showing evidence of IE. A significant negative predictor was a definite etiology of infection other than IE. Only one in 76 patients was diagnosed with both IE and infection at another site. CONCLUSIONS: The absence of positive predictors or the presence of a negative predictor indicate a near-zero probability of IE being detected by TTE. Use of clinical parameters may avoid up to 41% of unnecessary TTE examinations, increasing the likelihood that such a diagnosis will be correct.

Original languageEnglish
Pages (from-to)703-705
Number of pages3
JournalCanadian Journal of Cardiology
Volume25
Issue number12
DOIs
Publication statusPublished - 2009 Jan 1

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Endocarditis
Echocardiography
Infection
Endocardium
Prospective Studies
Pharmaceutical Preparations
Population

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Judicious use of transthoracic echocardiography in infective endocarditis screening",
abstract = "BACKGROUND: Patients with a very low probability of infective endocarditis (IE) do not benefit from transthoracic echocardiography (TTE). Because the term 'very low probability' has not yet been defined, the present prospective study sought to identify the population with a 'very low probability'. METHODS: TTE was performed between July 2005 and October 2006 in consecutive patients clinically suspected of having IE. Clinical parameters suggestive of IE and presence of infectious focus were recorded. RESULTS: Twenty-four (15.5{\%}) of 155 patients studied had positive findings on TTE. Significant positive predictors were embolic events, intravenous drug use, the presence of a prosthetic valve, positive blood cultures and immunological phenomena. The significant negative predictor was confirmed infection sites other than endocardium. Sixty-three (40.6{\%}) of 155 patients without positive predictors were found to have no vegetation. Thus, the collective absence of these predictors indicated a zero probability of TTE showing evidence of IE. A significant negative predictor was a definite etiology of infection other than IE. Only one in 76 patients was diagnosed with both IE and infection at another site. CONCLUSIONS: The absence of positive predictors or the presence of a negative predictor indicate a near-zero probability of IE being detected by TTE. Use of clinical parameters may avoid up to 41{\%} of unnecessary TTE examinations, increasing the likelihood that such a diagnosis will be correct.",
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Judicious use of transthoracic echocardiography in infective endocarditis screening. / Liu, Yen-Wen; Tsai, Wei-Chuan; Hsu, Chin-Hsin; Lin, Li Jen; Lee, Wei-Ting; Chen, Chun Hsiu; Chen, Jyh Hong.

In: Canadian Journal of Cardiology, Vol. 25, No. 12, 01.01.2009, p. 703-705.

Research output: Contribution to journalArticle

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