Kalanchosides A-C, new cytotoxic bufadienolides from the aerial parts of Kalanchoe gracilis

Pei Lin Wu; Yu Lin Hsu; Tian Shung Wu; K. F. Bastow; Kuo Hsiung Lee

doi:10.1021/ol061873m

Kalanchosides A-C, new cytotoxic bufadienolides from the aerial parts of Kalanchoe gracilis

Pei Lin Wu, Yu Lin Hsu, Tian Shung Wu, K. F. Bastow, Kuo Hsiung Lee

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Three new compounds, kalanchosides A-C (1-3), as well as five known compounds, were isolated from the aerial parts of Kalanchoe gracilis. The compound structures were determined by spectroscopic methods. All eight isolated compounds showed significant cytotoxic activity against a panel of human tumor cell lines, with potency reaching the nanomolar range. However, only bryophyllin B (8) inhibited HIV replication in H9 lymphocyte cells.

Original language	English
Pages (from-to)	5207-5210
Number of pages	4
Journal	Organic Letters
Volume	8
Issue number	23
DOIs	https://doi.org/10.1021/ol061873m
Publication status	Published - 2006 Nov 9

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/ol061873m

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abstract = "Three new compounds, kalanchosides A-C (1-3), as well as five known compounds, were isolated from the aerial parts of Kalanchoe gracilis. The compound structures were determined by spectroscopic methods. All eight isolated compounds showed significant cytotoxic activity against a panel of human tumor cell lines, with potency reaching the nanomolar range. However, only bryophyllin B (8) inhibited HIV replication in H9 lymphocyte cells.",

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AU - Bastow, K. F.

AU - Lee, Kuo Hsiung

PY - 2006/11/9

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N2 - Three new compounds, kalanchosides A-C (1-3), as well as five known compounds, were isolated from the aerial parts of Kalanchoe gracilis. The compound structures were determined by spectroscopic methods. All eight isolated compounds showed significant cytotoxic activity against a panel of human tumor cell lines, with potency reaching the nanomolar range. However, only bryophyllin B (8) inhibited HIV replication in H9 lymphocyte cells.

AB - Three new compounds, kalanchosides A-C (1-3), as well as five known compounds, were isolated from the aerial parts of Kalanchoe gracilis. The compound structures were determined by spectroscopic methods. All eight isolated compounds showed significant cytotoxic activity against a panel of human tumor cell lines, with potency reaching the nanomolar range. However, only bryophyllin B (8) inhibited HIV replication in H9 lymphocyte cells.

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Kalanchosides A-C, new cytotoxic bufadienolides from the aerial parts of Kalanchoe gracilis

Abstract

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