Lack of association between interleukin-1α polymorphism and Alzheimer disease or vascular dementia

Yu Min Kuo, Pao Chi Liao, Chingju Lin, Chih Wei Wu, Hsueh Meei Huang, Chih Chien Lin, Liang Jen Chuo

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Recently, a C/T polymorphism in the promoter region of the interleukin 1-α (IL-1α) gene (position -889) was reported to be associated with Alzheimer disease. In this study, the polymorphism of IL-1α was examined in patients with Alzheimer disease, vascular dementia, and nondemented controls in a Chinese population in Taiwan. No difference was found in the IL-1α. T allele frequency among the three groups. The predominant polymorphic allele (∼90%) of IL-1α was the C allele. The APOE4 allele was overrepresented in the AD cohort. The presence of the APOE4 allele did not influence the IL-1α genotype or allele distribution. The prevalence of the IL-1α T allele, in particular the homozygous form, was lower than in whites and may account for the lack of association between IL-1α C/T polymorphism and Alzheimer disease among Chinese in Taiwan. The presence of the heterozygous IL-1α T allele cannot be used for distinguishing Alzheimer disease or vascular dementia from controls.

Original languageEnglish
Pages (from-to)94-97
Number of pages4
JournalAlzheimer Disease and Associated Disorders
Volume17
Issue number2
DOIs
Publication statusPublished - 2003 Apr 1

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Lack of association between interleukin-1α polymorphism and Alzheimer disease or vascular dementia'. Together they form a unique fingerprint.

Cite this