Lack of association of C-Met-N375S sequence variant with lung cancer susceptibility and prognosis

Jiunn Min Shieh, Yen An Tang, Tsung Han Yang, Chih Yi Chen, Han Shui Hsu, Yi Hung Carol Tan, Ravi Salgia, Yi Ching Wang

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Background: Previously, we identified a sequence variant (N375S) of c-Met gene, however, its association with lung cancer risk and prognosis remain undefined. Patients and Methods: We investigated the genotype distribution of the c-Met-N375S sequence variant in 206 lung cancer patients and 207 non-cancer controls in the Taiwanese population by DNA sequencing. Results: Lung cancer patients with variant A/G and G/G genotypes showed 1.08-fold increased cancer risk when compared to patients with the wild-type A/A genotype (95% CI, 0.60-1.91). There were no significant differences in postoperative survival between c-Met-N375S and wild-type patients. In the cell model, the c-Met-N375S cells showed a decrease in cell death upon treatment with MET inhibitor SU11274 compared to wild-type cells. Conclusion: Our data suggest that the c-Met-N375S sequence variant may not play a significant role in cancer susceptibility and the prognosis of lung cancer patients. The correlation with chemoresponse of c-Met-N375S is worth further investigation in patients receiving MET therapy.

Original languageEnglish
Pages (from-to)988-994
Number of pages7
JournalInternational Journal of Medical Sciences
Volume10
Issue number8
DOIs
Publication statusPublished - 2013

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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