Langerhans cell histiocytosis as a possible differential diagnosis of painful scoliosis

Kuo Yuan Huang, Ruey Mo Lin, Jing Jou Yan, Chii Jeng Lin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We report on a 5-year 8-month-old boy suffering from spinal Langerhans cell histiocytosis (LCH), who had initial symptoms of back and abdominal pain, as well as tilting of the shoulder that mimicked hemivertebra of T10 with scoliosis, as revealed by radiography. The LCH-involved vertebra did not demonstrate the classic radiographic picture of vertebra plana until the vertebral body symmetrically collapsed about 6 months later, when the patient's scoliosis disappeared. The delayed diagnosis of LCH was confirmed by biopsy after another 6 months. Polyostotic lesions affecting C6, T5, T9-12, and L2 were found. This case represented an unusual presentation of LCH as an early disease entity, which resulted in a misdiagnosis of painful scoliosis. We believe we are the first to report LCH as a differential diagnosis of painful scoliosis.

Original languageEnglish
Pages (from-to)396-399
Number of pages4
JournalJoint Bone Spine
Volume74
Issue number4
DOIs
Publication statusPublished - 2007 Jul 1

Fingerprint

Langerhans Cell Histiocytosis
Scoliosis
Differential Diagnosis
Spine
Temazepam
Delayed Diagnosis
Back Pain
Diagnostic Errors
Radiography
Abdominal Pain
Biopsy

All Science Journal Classification (ASJC) codes

  • Rheumatology

Cite this

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abstract = "We report on a 5-year 8-month-old boy suffering from spinal Langerhans cell histiocytosis (LCH), who had initial symptoms of back and abdominal pain, as well as tilting of the shoulder that mimicked hemivertebra of T10 with scoliosis, as revealed by radiography. The LCH-involved vertebra did not demonstrate the classic radiographic picture of vertebra plana until the vertebral body symmetrically collapsed about 6 months later, when the patient's scoliosis disappeared. The delayed diagnosis of LCH was confirmed by biopsy after another 6 months. Polyostotic lesions affecting C6, T5, T9-12, and L2 were found. This case represented an unusual presentation of LCH as an early disease entity, which resulted in a misdiagnosis of painful scoliosis. We believe we are the first to report LCH as a differential diagnosis of painful scoliosis.",
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Langerhans cell histiocytosis as a possible differential diagnosis of painful scoliosis. / Huang, Kuo Yuan; Lin, Ruey Mo; Yan, Jing Jou; Lin, Chii Jeng.

In: Joint Bone Spine, Vol. 74, No. 4, 01.07.2007, p. 396-399.

Research output: Contribution to journalArticle

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