Lectin immunohistochemistry study of nasal inverted papilloma and associated neoplasms

Sheen-Yie Fang, Yin Tai Jin, Masuru Ohyama

Research output: Contribution to journalArticle

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Abstract

Background: We aimed to investigate the tumor biology of nasal IP and identify the biological characteristics associated with early diagnosis and malignant transformation. Materials and Methods: Lectins immunohistochemitry were performed on inverted papilloma (IP), and associated neoplasms. IP synchronized with polyp or squamous cell carcinoma (SCC) and IP metachronized with SCC were analyzed and correlated to clinical information. Results: Canavalia ensiformis (ConA) and Arachis hypogaea (PNA) with neuraminidase pretreatment (NA-PNA) showed similar staining in both the IP and SCC portions of the IP synchronized with SCC. The IP and polyp portions of an IP synchronized polyp had positive NA-PNA staining, while papilloma and polyps alone had negative staining. Strong NA-PNA staining in the IP (transformed to SCC) showed significant differences from IP. Conclusion: These biological characteristics define IP as a premalignant neoplasm. NA-PNA staining may be helpful for an early detection of IP. Strong NA-PNA staining in IP may predict malignant transformation.

Original languageEnglish
Pages (from-to)3691-3696
Number of pages6
JournalAnticancer Research
Volume17
Issue number5 A
Publication statusPublished - 1997 Sep 1

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Inverted Papilloma
Nose
Lectins
Immunohistochemistry
Neoplasms
Squamous Cell Carcinoma
Polyps
Staining and Labeling
Papilloma
Canavalia
Negative Staining
Neuraminidase

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Fang, Sheen-Yie ; Jin, Yin Tai ; Ohyama, Masuru. / Lectin immunohistochemistry study of nasal inverted papilloma and associated neoplasms. In: Anticancer Research. 1997 ; Vol. 17, No. 5 A. pp. 3691-3696.
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Lectin immunohistochemistry study of nasal inverted papilloma and associated neoplasms. / Fang, Sheen-Yie; Jin, Yin Tai; Ohyama, Masuru.

In: Anticancer Research, Vol. 17, No. 5 A, 01.09.1997, p. 3691-3696.

Research output: Contribution to journalArticle

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N2 - Background: We aimed to investigate the tumor biology of nasal IP and identify the biological characteristics associated with early diagnosis and malignant transformation. Materials and Methods: Lectins immunohistochemitry were performed on inverted papilloma (IP), and associated neoplasms. IP synchronized with polyp or squamous cell carcinoma (SCC) and IP metachronized with SCC were analyzed and correlated to clinical information. Results: Canavalia ensiformis (ConA) and Arachis hypogaea (PNA) with neuraminidase pretreatment (NA-PNA) showed similar staining in both the IP and SCC portions of the IP synchronized with SCC. The IP and polyp portions of an IP synchronized polyp had positive NA-PNA staining, while papilloma and polyps alone had negative staining. Strong NA-PNA staining in the IP (transformed to SCC) showed significant differences from IP. Conclusion: These biological characteristics define IP as a premalignant neoplasm. NA-PNA staining may be helpful for an early detection of IP. Strong NA-PNA staining in IP may predict malignant transformation.

AB - Background: We aimed to investigate the tumor biology of nasal IP and identify the biological characteristics associated with early diagnosis and malignant transformation. Materials and Methods: Lectins immunohistochemitry were performed on inverted papilloma (IP), and associated neoplasms. IP synchronized with polyp or squamous cell carcinoma (SCC) and IP metachronized with SCC were analyzed and correlated to clinical information. Results: Canavalia ensiformis (ConA) and Arachis hypogaea (PNA) with neuraminidase pretreatment (NA-PNA) showed similar staining in both the IP and SCC portions of the IP synchronized with SCC. The IP and polyp portions of an IP synchronized polyp had positive NA-PNA staining, while papilloma and polyps alone had negative staining. Strong NA-PNA staining in the IP (transformed to SCC) showed significant differences from IP. Conclusion: These biological characteristics define IP as a premalignant neoplasm. NA-PNA staining may be helpful for an early detection of IP. Strong NA-PNA staining in IP may predict malignant transformation.

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