Abstract
Background: We aimed to investigate the tumor biology of nasal IP and identify the biological characteristics associated with early diagnosis and malignant transformation. Materials and Methods: Lectins immunohistochemitry were performed on inverted papilloma (IP), and associated neoplasms. IP synchronized with polyp or squamous cell carcinoma (SCC) and IP metachronized with SCC were analyzed and correlated to clinical information. Results: Canavalia ensiformis (ConA) and Arachis hypogaea (PNA) with neuraminidase pretreatment (NA-PNA) showed similar staining in both the IP and SCC portions of the IP synchronized with SCC. The IP and polyp portions of an IP synchronized polyp had positive NA-PNA staining, while papilloma and polyps alone had negative staining. Strong NA-PNA staining in the IP (transformed to SCC) showed significant differences from IP. Conclusion: These biological characteristics define IP as a premalignant neoplasm. NA-PNA staining may be helpful for an early detection of IP. Strong NA-PNA staining in IP may predict malignant transformation.
| Original language | English |
|---|---|
| Pages (from-to) | 3691-3696 |
| Number of pages | 6 |
| Journal | Anticancer Research |
| Volume | 17 |
| Issue number | 5 A |
| Publication status | Published - 1997 Sep 1 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
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Lectin immunohistochemistry study of nasal inverted papilloma and associated neoplasms. / Fang, Sheen-Yie; Jin, Yin Tai; Ohyama, Masuru.
In: Anticancer Research, Vol. 17, No. 5 A, 01.09.1997, p. 3691-3696.Research output: Contribution to journal › Article
TY - JOUR
T1 - Lectin immunohistochemistry study of nasal inverted papilloma and associated neoplasms
AU - Fang, Sheen-Yie
AU - Jin, Yin Tai
AU - Ohyama, Masuru
PY - 1997/9/1
Y1 - 1997/9/1
N2 - Background: We aimed to investigate the tumor biology of nasal IP and identify the biological characteristics associated with early diagnosis and malignant transformation. Materials and Methods: Lectins immunohistochemitry were performed on inverted papilloma (IP), and associated neoplasms. IP synchronized with polyp or squamous cell carcinoma (SCC) and IP metachronized with SCC were analyzed and correlated to clinical information. Results: Canavalia ensiformis (ConA) and Arachis hypogaea (PNA) with neuraminidase pretreatment (NA-PNA) showed similar staining in both the IP and SCC portions of the IP synchronized with SCC. The IP and polyp portions of an IP synchronized polyp had positive NA-PNA staining, while papilloma and polyps alone had negative staining. Strong NA-PNA staining in the IP (transformed to SCC) showed significant differences from IP. Conclusion: These biological characteristics define IP as a premalignant neoplasm. NA-PNA staining may be helpful for an early detection of IP. Strong NA-PNA staining in IP may predict malignant transformation.
AB - Background: We aimed to investigate the tumor biology of nasal IP and identify the biological characteristics associated with early diagnosis and malignant transformation. Materials and Methods: Lectins immunohistochemitry were performed on inverted papilloma (IP), and associated neoplasms. IP synchronized with polyp or squamous cell carcinoma (SCC) and IP metachronized with SCC were analyzed and correlated to clinical information. Results: Canavalia ensiformis (ConA) and Arachis hypogaea (PNA) with neuraminidase pretreatment (NA-PNA) showed similar staining in both the IP and SCC portions of the IP synchronized with SCC. The IP and polyp portions of an IP synchronized polyp had positive NA-PNA staining, while papilloma and polyps alone had negative staining. Strong NA-PNA staining in the IP (transformed to SCC) showed significant differences from IP. Conclusion: These biological characteristics define IP as a premalignant neoplasm. NA-PNA staining may be helpful for an early detection of IP. Strong NA-PNA staining in IP may predict malignant transformation.
UR - http://www.scopus.com/inward/record.url?scp=0030728785&partnerID=8YFLogxK
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M3 - Article
C2 - 9413225
AN - SCOPUS:0030728785
VL - 17
SP - 3691
EP - 3696
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 5 A
ER -