Lectin immunohistochemistry study of nasal inverted papilloma and associated neoplasms

Sheen Yie Fang, Yin Tai Jin, Masuru Ohyama

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1 Citation (Scopus)


Background: We aimed to investigate the tumor biology of nasal IP and identify the biological characteristics associated with early diagnosis and malignant transformation. Materials and Methods: Lectins immunohistochemitry were performed on inverted papilloma (IP), and associated neoplasms. IP synchronized with polyp or squamous cell carcinoma (SCC) and IP metachronized with SCC were analyzed and correlated to clinical information. Results: Canavalia ensiformis (ConA) and Arachis hypogaea (PNA) with neuraminidase pretreatment (NA-PNA) showed similar staining in both the IP and SCC portions of the IP synchronized with SCC. The IP and polyp portions of an IP synchronized polyp had positive NA-PNA staining, while papilloma and polyps alone had negative staining. Strong NA-PNA staining in the IP (transformed to SCC) showed significant differences from IP. Conclusion: These biological characteristics define IP as a premalignant neoplasm. NA-PNA staining may be helpful for an early detection of IP. Strong NA-PNA staining in IP may predict malignant transformation.

Original languageEnglish
Pages (from-to)3691-3696
Number of pages6
JournalAnticancer research
Issue number5 A
Publication statusPublished - 1997 Sep

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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