Lectin of Concanavalin A as an anti-hepatoma therapeutic agent

Huan Yao Lei, Chih-Peng Chang

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Liver cancer is the predominant cause of cancer mortality in males of Southern China and Taiwan. The current therapy is not satisfactory, and more effective treatments are needed. In the search for new therapies for liver tumor, we found that Concanavalin A (Con A), a lectin from Jack bean seeds, can have a potent anti-hepatoma effect. Con A after binding to the mannose moiety on the cell membrane glycoprotein is internalized preferentially to the mitochondria. An autophagy is triggered which leads to cell death. Con A as a T cell mitogen subsequently activates the immune response in the liver and results in the eradication of the tumor in a murine in situ hepatoma model. The liver tumor nodule formation is inhibited by the CD8+T cells, and a tumor antigen-specific immune memory is established during the hepatic inflammation. The dual properties (autophagic cytotoxicity and immunomodulation) via the specific carbohydrate binding let Con A exert a potent anti-hepatoma therapeutic effect. The novel mechanism of the Con A anti-hepatoma effect is discussed. The prototype of Con with an anti-hepatoma activity gives support to the search for other natural lectins as anti-cancer compounds.

Original languageEnglish
Article number10
JournalJournal of biomedical science
Volume16
Issue number1
DOIs
Publication statusPublished - 2009 Apr 6

Fingerprint

Concanavalin A
Lectins
Hepatocellular Carcinoma
Liver
Tumors
T-cells
Neoplasms
T-Lymphocytes
Therapeutics
Mitochondria
Jacks
Immunomodulation
Membrane Glycoproteins
Autophagy
Neoplasm Antigens
Therapeutic Uses
Cell death
Cell membranes
Liver Neoplasms
Cytotoxicity

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

Cite this

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Lectin of Concanavalin A as an anti-hepatoma therapeutic agent. / Lei, Huan Yao; Chang, Chih-Peng.

In: Journal of biomedical science, Vol. 16, No. 1, 10, 06.04.2009.

Research output: Contribution to journalArticle

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AB - Liver cancer is the predominant cause of cancer mortality in males of Southern China and Taiwan. The current therapy is not satisfactory, and more effective treatments are needed. In the search for new therapies for liver tumor, we found that Concanavalin A (Con A), a lectin from Jack bean seeds, can have a potent anti-hepatoma effect. Con A after binding to the mannose moiety on the cell membrane glycoprotein is internalized preferentially to the mitochondria. An autophagy is triggered which leads to cell death. Con A as a T cell mitogen subsequently activates the immune response in the liver and results in the eradication of the tumor in a murine in situ hepatoma model. The liver tumor nodule formation is inhibited by the CD8+T cells, and a tumor antigen-specific immune memory is established during the hepatic inflammation. The dual properties (autophagic cytotoxicity and immunomodulation) via the specific carbohydrate binding let Con A exert a potent anti-hepatoma therapeutic effect. The novel mechanism of the Con A anti-hepatoma effect is discussed. The prototype of Con with an anti-hepatoma activity gives support to the search for other natural lectins as anti-cancer compounds.

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