Left ventricular systolic strain in chronic kidney disease and hemodialysis patients

Yen Wen Liu, Chi Ting Su, Yao Yi Huang, Chun Shin Yang, Jenq Wen Huang, Mao Ting Yang, Jyh Hong Chen, Wei Chuan Tsai

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)


Background: The impact of chronic kidney disease (CKD) and hemodialysis on heart function is not fully understood. We aimed to investigate the influence of different stages of CKD and maintenance hemodialysis on heart function. Methods: One hundred fifty-three patients were categorized into 3 subgroups [56 without CKD as controls; 37 with moderate-advanced CKD, stages 3, 4 or 5, and 60 with end-stage renal disease (ESRD) undergoing maintenance hemodialysis]. Left ventricular (LV) function was assessed by conventional echocardiography and 2-dimensional speckle-tracking echocardiography with strain analysis (2D strain analysis). Results: There was no significant difference of gender, age and LV ejection fraction among groups. Compared with controls, global peak systolic longitudinal strain (GSl), circumferential strain and strain rate were decreased in the CKD group. Along with the decline of renal function, GSl deteriorated. Moreover, compared with moderate-advanced CKD patients, GSl, circumferential strain and strain rate were better in ESRD group receiving maintenance hemodialysis. Conclusions: Worsening renal function was associated with a reduction of systolic function, and could be quantified by 2D strain analysis. The hemodialysis patients have better LV systolic function than the moderate-advanced CKD patients.

Original languageEnglish
Pages (from-to)84-90
Number of pages7
JournalAmerican Journal of Nephrology
Issue number1
Publication statusPublished - 2011 Jan

All Science Journal Classification (ASJC) codes

  • Nephrology


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