Level of Inflammation-Related DNA Adducts in Human Tissues

Tomonari Matsuda, Pei Hsin Chou, Haruhiko Sugimura

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Formation of DNA adducts is thought to be an initial event of carcinogenesis. Improvement in the performance of liquid chromatography-tandem mass spectrometry (LC/MS-MS) enables us to detect trace amounts of DNA adducts in tissue samples. Recently, the authors carried out a comprehensive analysis of DNA adducts by using LC/MS-MS and found that DNA adducts derived from 4-oxo-2(E)-nonenal (4-ONE) and 4-oxo-2(E)-hexenal (4-OHE) were the major DNA adduct types presented in various human tissues. This chapter describes the level of 4-ONE- and 4-OHE-derived DNA adducts in human tissues, the genotoxicity of the adducts, and their possible relation to inflammation. Inflammation-related DNA adducts produced by 4-ONE and 4-OHE are present ubiquitously in human tissues and are even predominant in some cases. This suggests a possible link between inflammation and cancer. The mechanisms involved in the production of 4-OHE by n-3 PUFAs under inflammation have not yet been well elucidated.

Original languageEnglish
Title of host publicationCancer and Inflammation Mechanisms
Subtitle of host publicationChemical, Biological, and Clinical Aspects
PublisherWiley-Blackwell
Pages75-81
Number of pages7
ISBN (Electronic)9781118826621
ISBN (Print)9781118160305
DOIs
Publication statusPublished - 2014 Mar 31

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)
  • Nursing(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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