Level of Inflammation-Related DNA Adducts in Human Tissues

Tomonari Matsuda, Pei Hsin Chou, Haruhiko Sugimura

Research output: Chapter in Book/Report/Conference proceedingChapter


Formation of DNA adducts is thought to be an initial event of carcinogenesis. Improvement in the performance of liquid chromatography-tandem mass spectrometry (LC/MS-MS) enables us to detect trace amounts of DNA adducts in tissue samples. Recently, the authors carried out a comprehensive analysis of DNA adducts by using LC/MS-MS and found that DNA adducts derived from 4-oxo-2(E)-nonenal (4-ONE) and 4-oxo-2(E)-hexenal (4-OHE) were the major DNA adduct types presented in various human tissues. This chapter describes the level of 4-ONE- and 4-OHE-derived DNA adducts in human tissues, the genotoxicity of the adducts, and their possible relation to inflammation. Inflammation-related DNA adducts produced by 4-ONE and 4-OHE are present ubiquitously in human tissues and are even predominant in some cases. This suggests a possible link between inflammation and cancer. The mechanisms involved in the production of 4-OHE by n-3 PUFAs under inflammation have not yet been well elucidated.

Original languageEnglish
Title of host publicationCancer and Inflammation Mechanisms
Subtitle of host publicationChemical, Biological, and Clinical Aspects
Number of pages7
ISBN (Electronic)9781118826621
ISBN (Print)9781118160305
Publication statusPublished - 2014 Mar 31

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)
  • Nursing(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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