Lidocaine for prolonged and intensified spinal anesthesia by coadministration of propranolol in the rat

Yu Wen Chen, Chin Chen Chu, Yu Chung Chen, Ching Hsia Hung, Yung Tsung Li, Jhi Joung Wang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Although the coadministration of lidocaine with propranolol interferes with the metabolic profile (pharmacokinetics), its pharmacodynamics is still unclear. In this report, we investigate whether propranolol can potentiate the effect of lidocaine. Rats received spinal anesthesia with lidocaine co-injected with propranolol. After intrathecal injections of drugs in rats, three neurobehavioral examinations (motor function, proprioception, and nociception) were performed. We showed that lidocaine and propranolol elicited a spinal blockade in motor function, proprioception, and nociception. Propranolol at the dose of 0.82μmol/kg produced no spinal anesthesia. Co-administration of lidocaine [50% effective dose (ED 50) or ED 95] and propranolol (0.82μmol/kg) produced greater spinal anesthesia than lidocaine (ED 50 or ED 95), respectively. These preclinical findings demonstrated that propranolol and lidocaine displayed spinal anesthesia. When combined with propranolol, lidocaine elicited a supra-additive effect of spinal anesthesia.

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalNeuroscience Letters
Volume503
Issue number1
DOIs
Publication statusPublished - 2011 Sep 26

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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