Light distribution modulated diffuse reflectance spectroscopy

Pin Yuan Huang, Chun Yu Chien, Chia-Rong Sheu, Yu Wen Chen, Sheng-Hao Tseng

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Typically, a diffuse reflectance spectroscopy (DRS) system employing a continuous wave light source would need to acquire diffuse reflectances measured at multiple source-detector separations for determining the absorption and reduced scattering coefficients of turbid samples. This results in a multi-fiber probe structure and an indefinite probing depth. Here we present a novel DRS method that can utilize a few diffuse reflectances measured at one source-detector separation for recovering the optical properties of samples. The core of innovation is a liquid crystal (LC) cell whose scattering property can be modulated by the bias voltage. By placing the LC cell between the light source and the sample, the spatial distribution of light in the sample can be varied as the scattering property of the LC cell modulated by the bias voltage, and this would induce intensity variation of the collected diffuse reflectance. From a series of Monte Carlo simulations and phantom measurements, we found that this new light distribution modulated DRS (LDM DRS) system was capable of accurately recover the absorption and scattering coefficients of turbid samples and its probing depth only varied by less than 3% over the full bias voltage variation range. Our results suggest that this LDM DRS platform could be developed to various low-cost, efficient, and compact systems for in-vivo superficial tissue investigation.

Original languageEnglish
Pages (from-to)2118-2129
Number of pages12
JournalBiomedical Optics Express
Volume7
Issue number6
DOIs
Publication statusPublished - 2016 Jun 1

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Spectrum Analysis
Liquid Crystals
reflectance
Light
spectroscopy
liquid crystals
scattering coefficients
light sources
electric potential
cells
detectors
scattering
continuous radiation
absorptivity
spatial distribution
Costs and Cost Analysis
platforms
optical properties
fibers
probes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

Cite this

Huang, Pin Yuan ; Chien, Chun Yu ; Sheu, Chia-Rong ; Chen, Yu Wen ; Tseng, Sheng-Hao. / Light distribution modulated diffuse reflectance spectroscopy. In: Biomedical Optics Express. 2016 ; Vol. 7, No. 6. pp. 2118-2129.
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Light distribution modulated diffuse reflectance spectroscopy. / Huang, Pin Yuan; Chien, Chun Yu; Sheu, Chia-Rong; Chen, Yu Wen; Tseng, Sheng-Hao.

In: Biomedical Optics Express, Vol. 7, No. 6, 01.06.2016, p. 2118-2129.

Research output: Contribution to journalArticle

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