Light triggering goldsomes enable local NO-generation and alleviate pathological vasoconstriction

I. Ju Lee, Po Tsung Kao, Shao An Hung, Zih Wun Wang, Hui Jen Lin, Wei Tien Chang, Chen Sheng Yeh, Ian Liau

Research output: Contribution to journalArticlepeer-review

Abstract

While nitric oxide (NO) can remedy vasoconstriction, inhalation of NO may cause systematic toxicity. We report a goldsome, which comprises a hollowed poly(lactic-co-glycolic acid) (PLGA) polymersome with S-nitrosoglutathione (GSNO, a NO donor) molecules and gold nanoparticles (Au NPs) incorporated in its hydrophilic core and hydrophobic membrane, respectively. Photothermal heating caused breakdown of polymersomes and enabled NO generation through reaction between GSNO and Au NPs. Photo-illumination at the zebrafish head led to local NO generation and selective cerebral vasodilation while it had little effects in regions away from the illumination site, and effectively mitigated hypoxia induced cerebral vasoconstriction. We demonstrate a translational potential by showing photo-stimulated NO generation with a clinical intravascular optical catheter. In conclusion, the goldsome, which enables light stimulated local NO generation and can be delivered with clinical intravascular optical catheters, should extend applications of NO therapies while surmounting limitations associated with systemic administration.

Original languageEnglish
Article number102282
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume30
DOIs
Publication statusPublished - 2020 Nov

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Light triggering goldsomes enable local NO-generation and alleviate pathological vasoconstriction'. Together they form a unique fingerprint.

Cite this