TY - JOUR
T1 - Light triggering goldsomes enable local NO-generation and alleviate pathological vasoconstriction
AU - Lee, I. Ju
AU - Kao, Po Tsung
AU - Hung, Shao An
AU - Wang, Zih Wun
AU - Lin, Hui Jen
AU - Chang, Wei Tien
AU - Yeh, Chen Sheng
AU - Liau, Ian
N1 - Funding Information:
Sources of funding: This work is supported by the Ministry of Science and Technology (Grant No. 105-2627-M-009-011 , 106-2113-M-009-022-MY3 , 106-2627-M-009-005 , 107-3017-F009-003 , 107-2113-M-006-004-MY2 , and 108-2119-M-002-027 ), the Center for Emergent Functional Matter Science of National Chiao Tung University , and the Center of Applied Nanomedicine of National Cheng Kung University under the Featured Areas Research Center Program within the framework of the Higher Education Sprout Project of the Ministry of Education (MOE) in Taiwan.
Funding Information:
Sources of funding: This work is supported by the Ministry of Science and Technology (Grant No. 105-2627-M-009-011, 106-2113-M-009-022-MY3, 106-2627-M-009-005, 107-3017-F009-003, 107-2113-M-006-004-MY2, and 108-2119-M-002-027), the Center for Emergent Functional Matter Science of National Chiao Tung University, and the Center of Applied Nanomedicine of National Cheng Kung University under the Featured Areas Research Center Program within the framework of the Higher Education Sprout Project of the Ministry of Education (MOE) in Taiwan.This work is supported by Ministry of Science and Technology, Taiwan (Grant No. 105-2627-M-009-011, 106-2113-M-009-022-MY3, 106-2627-M-009-005, 107-3017-F009-003, 107-2113-M-006-004-MY2) and Ministry of Education, Taiwan (SPROUT Project-Center for Emergent Functional Matter Science of National Chiao Tung University). Additional support was provided by the Center of Applied Nanomedicine, National Cheng Kung University under the Featured Areas Research Center Program within the framework of the Higher Education Sprout Project of the Ministry of Education (MOE) in Taiwan. We thank NCTU, NCKU and NTUH of Taiwan for generous support, and the Taiwan Zebrafish Core Facility (NSC101-2321-B400-014) for supporting the source of zebrafish.
Funding Information:
This work is supported by Ministry of Science and Technology, Taiwan (Grant No. 105-2627-M-009-011 , 106-2113-M-009-022-MY3 , 106-2627-M-009-005 , 107-3017-F009-003 , 107-2113-M-006-004-MY2 ) and Ministry of Education, Taiwan (SPROUT Project-Center for Emergent Functional Matter Science of National Chiao Tung University). Additional support was provided by the Center of Applied Nanomedicine, National Cheng Kung University under the Featured Areas Research Center Program within the framework of the Higher Education Sprout Project of the Ministry of Education (MOE) in Taiwan. We thank NCTU, NCKU and NTUH of Taiwan for generous support, and the Taiwan Zebrafish Core Facility ( NSC101-2321-B400-014 ) for supporting the source of zebrafish.
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/11
Y1 - 2020/11
N2 - While nitric oxide (NO) can remedy vasoconstriction, inhalation of NO may cause systematic toxicity. We report a goldsome, which comprises a hollowed poly(lactic-co-glycolic acid) (PLGA) polymersome with S-nitrosoglutathione (GSNO, a NO donor) molecules and gold nanoparticles (Au NPs) incorporated in its hydrophilic core and hydrophobic membrane, respectively. Photothermal heating caused breakdown of polymersomes and enabled NO generation through reaction between GSNO and Au NPs. Photo-illumination at the zebrafish head led to local NO generation and selective cerebral vasodilation while it had little effects in regions away from the illumination site, and effectively mitigated hypoxia induced cerebral vasoconstriction. We demonstrate a translational potential by showing photo-stimulated NO generation with a clinical intravascular optical catheter. In conclusion, the goldsome, which enables light stimulated local NO generation and can be delivered with clinical intravascular optical catheters, should extend applications of NO therapies while surmounting limitations associated with systemic administration.
AB - While nitric oxide (NO) can remedy vasoconstriction, inhalation of NO may cause systematic toxicity. We report a goldsome, which comprises a hollowed poly(lactic-co-glycolic acid) (PLGA) polymersome with S-nitrosoglutathione (GSNO, a NO donor) molecules and gold nanoparticles (Au NPs) incorporated in its hydrophilic core and hydrophobic membrane, respectively. Photothermal heating caused breakdown of polymersomes and enabled NO generation through reaction between GSNO and Au NPs. Photo-illumination at the zebrafish head led to local NO generation and selective cerebral vasodilation while it had little effects in regions away from the illumination site, and effectively mitigated hypoxia induced cerebral vasoconstriction. We demonstrate a translational potential by showing photo-stimulated NO generation with a clinical intravascular optical catheter. In conclusion, the goldsome, which enables light stimulated local NO generation and can be delivered with clinical intravascular optical catheters, should extend applications of NO therapies while surmounting limitations associated with systemic administration.
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U2 - 10.1016/j.nano.2020.102282
DO - 10.1016/j.nano.2020.102282
M3 - Article
C2 - 32771420
AN - SCOPUS:85090039659
SN - 1549-9634
VL - 30
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
M1 - 102282
ER -