Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles

Ronnie H. Fang, Che Ming J. Hu, Kevin N.H. Chen, Brian T. Luk, Cody W. Carpenter, Weiwei Gao, Shulin Li, Dong Er Zhang, Weiyue Lu, Liangfang Zhang

Research output: Contribution to journalArticlepeer-review

121 Citations (Scopus)

Abstract

RBC membrane-cloaked polymeric nanoparticles represent an emerging nanocarrier platform with extended circulation in vivo. A lipid-insertion method is employed to functionalize these nanoparticles without the need for direct chemical conjugation. Insertion of both folate and the nucleolin-targeting aptamer AS1411 shows receptor-specific targeting against model cancer cell lines.

Original languageEnglish
Pages (from-to)8884-8888
Number of pages5
JournalNanoscale
Volume5
Issue number19
DOIs
Publication statusPublished - 2013 Oct 7

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

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