Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles

Ronnie H. Fang; Che Ming J. Hu; Kevin N.H. Chen; Brian T. Luk; Cody W. Carpenter; Weiwei Gao; Shulin Li; Dong Er Zhang; Weiyue Lu; Liangfang Zhang

doi:10.1039/c3nr03064d

Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles

Ronnie H. Fang
, Che Ming J. Hu
, Kevin N.H. Chen
, Brian T. Luk
, Cody W. Carpenter
, Weiwei Gao
, Shulin Li
, Dong Er Zhang
, Weiyue Lu
, Liangfang Zhang

Center of Applied Nanomedicine

Research output: Contribution to journal › Article › peer-review

285 Citations (Scopus)

Abstract

RBC membrane-cloaked polymeric nanoparticles represent an emerging nanocarrier platform with extended circulation in vivo. A lipid-insertion method is employed to functionalize these nanoparticles without the need for direct chemical conjugation. Insertion of both folate and the nucleolin-targeting aptamer AS1411 shows receptor-specific targeting against model cancer cell lines.

Original language	English
Pages (from-to)	8884-8888
Number of pages	5
Journal	Nanoscale
Volume	5
Issue number	19
DOIs	https://doi.org/10.1039/c3nr03064d
Publication status	Published - 2013 Oct 7

All Science Journal Classification (ASJC) codes

General Materials Science

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10.1039/c3nr03064d

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title = "Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles",

abstract = "RBC membrane-cloaked polymeric nanoparticles represent an emerging nanocarrier platform with extended circulation in vivo. A lipid-insertion method is employed to functionalize these nanoparticles without the need for direct chemical conjugation. Insertion of both folate and the nucleolin-targeting aptamer AS1411 shows receptor-specific targeting against model cancer cell lines.",

author = "Fang, \{Ronnie H.\} and Hu, \{Che Ming J.\} and Chen, \{Kevin N.H.\} and Luk, \{Brian T.\} and Carpenter, \{Cody W.\} and Weiwei Gao and Shulin Li and Zhang, \{Dong Er\} and Weiyue Lu and Liangfang Zhang",

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AU - Fang, Ronnie H.

AU - Hu, Che Ming J.

AU - Chen, Kevin N.H.

AU - Luk, Brian T.

AU - Carpenter, Cody W.

AU - Gao, Weiwei

AU - Li, Shulin

AU - Zhang, Dong Er

AU - Lu, Weiyue

AU - Zhang, Liangfang

PY - 2013/10/7

Y1 - 2013/10/7

N2 - RBC membrane-cloaked polymeric nanoparticles represent an emerging nanocarrier platform with extended circulation in vivo. A lipid-insertion method is employed to functionalize these nanoparticles without the need for direct chemical conjugation. Insertion of both folate and the nucleolin-targeting aptamer AS1411 shows receptor-specific targeting against model cancer cell lines.

AB - RBC membrane-cloaked polymeric nanoparticles represent an emerging nanocarrier platform with extended circulation in vivo. A lipid-insertion method is employed to functionalize these nanoparticles without the need for direct chemical conjugation. Insertion of both folate and the nucleolin-targeting aptamer AS1411 shows receptor-specific targeting against model cancer cell lines.

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UR - https://www.scopus.com/pages/publications/84884267488#tab=citedBy

U2 - 10.1039/c3nr03064d

DO - 10.1039/c3nr03064d

M3 - Article

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AN - SCOPUS:84884267488

SN - 2040-3364

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SP - 8884

EP - 8888

JO - Nanoscale

JF - Nanoscale

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ER -

Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles

Abstract

All Science Journal Classification (ASJC) codes

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