TY - JOUR
T1 - Lipids and alzheimer’s disease
AU - Kao, Yu Chia
AU - Ho, Pei Chuan
AU - Tu, Yuan Kun
AU - Jou, I. Ming
AU - Tsai, Kuen Jer
N1 - Funding Information:
Funding: This study was supported by grants from Ministry of Science and Technology, Taiwan (MOST-105-2628-B-006-016-MY3 and MOST-106-2628-B-006-001-MY4) and from extramural research projects of E-DA medical research department in conjunction with National Cheng Kung University (NCKUEDA 10211, NCKUEDA 10306 and NCKUEDA 10619).
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/2/2
Y1 - 2020/2/2
N2 - Lipids, as the basic component of cell membranes, play an important role in human health as well as brain function. The brain is highly enriched in lipids, and disruption of lipid homeostasis is related to neurologic disorders as well as neurodegenerative diseases such as Alzheimer’s disease (AD). Aging is associated with changes in lipid composition. Alterations of fatty acids at the level of lipid rafts and cerebral lipid peroxidation were found in the early stage of AD. Genetic and environmental factors such as apolipoprotein and lipid transporter carrying status and dietary lipid content are associated with AD. Insight into the connection between lipids and AD is crucial to unraveling the metabolic aspects of this puzzling disease. Recent advances in lipid analytical methodology have led us to gain an in-depth understanding on lipids. As a result, lipidomics have becoming a hot topic of investigation in AD, in order to find biomarkers for disease prediction, diagnosis, and prevention, with the ultimate goal of discovering novel therapeutics.
AB - Lipids, as the basic component of cell membranes, play an important role in human health as well as brain function. The brain is highly enriched in lipids, and disruption of lipid homeostasis is related to neurologic disorders as well as neurodegenerative diseases such as Alzheimer’s disease (AD). Aging is associated with changes in lipid composition. Alterations of fatty acids at the level of lipid rafts and cerebral lipid peroxidation were found in the early stage of AD. Genetic and environmental factors such as apolipoprotein and lipid transporter carrying status and dietary lipid content are associated with AD. Insight into the connection between lipids and AD is crucial to unraveling the metabolic aspects of this puzzling disease. Recent advances in lipid analytical methodology have led us to gain an in-depth understanding on lipids. As a result, lipidomics have becoming a hot topic of investigation in AD, in order to find biomarkers for disease prediction, diagnosis, and prevention, with the ultimate goal of discovering novel therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=85079842481&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85079842481&partnerID=8YFLogxK
U2 - 10.3390/ijms21041505
DO - 10.3390/ijms21041505
M3 - Review article
C2 - 32098382
AN - SCOPUS:85079842481
SN - 1661-6596
VL - 21
JO - International journal of molecular sciences
JF - International journal of molecular sciences
IS - 4
M1 - 1505
ER -