Liposome-like nanostructures for drug delivery

Weiwei Gao, Che Ming J. Hu, Ronnie H. Fang, Liangfang Zhang

Research output: Contribution to journalArticlepeer-review

93 Citations (Scopus)

Abstract

Liposomes are a class of well-established drug carriers that have found numerous therapeutic applications. The success of liposomes, together with recent advancements in nanotechnology, has motivated the development of various novel liposome-like nanostructures with improved drug delivery performance. These nanostructures can be categorized into five major varieties, namely: (1) polymer-stabilized liposomes, (2) nanoparticle-stabilized liposomes, (3) core-shell lipid-polymer hybrid nanoparticles, (4) natural membrane-derived vesicles, and (5) natural membrane coated nanoparticles. They have received significant attention and have become popular drug delivery platforms. Herein, we discuss the unique strengths of these liposome-like platforms in drug delivery, with a particular emphasis on how liposome-inspired novel designs have led to improved therapeutic efficacy, and review recent progress made by each platform in advancing healthcare.

Original languageEnglish
Pages (from-to)6569-6585
Number of pages17
JournalJournal of Materials Chemistry B
Volume1
Issue number48
DOIs
Publication statusPublished - 2013 Dec 28

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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