Localised heating of tumours utilising injectable magnetic nanoparticles for hyperthermia cancer therapy

H. Y. Tseng, G. B. Lee, C. Y. Lee, Y. H. Shih, X. Z. Lin

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

This study reports an investigation of hyperthermia cancer therapy utilising an alternating magnetic field to induce a localised temperature increase on tumours by using injectable magnetic nanoparticles. In-vitro and in-vivo experiments represent the feasibility of hyperthermia cancer therapy. A feedback temperature control system was first developed to keep the nanoparticles at a constant temperature to prevent overheating in the tumours such that a safer and more precise cancer therapy becomes feasible. By using the feedback temperature control system, magnetic nanoparticles can be heated up to the specific constant temperatures, 37, 40, 42, 45, 46 and 47°C, respectively, with a variation less than 0.2°C. With this approach, the in-vitro survival rate of tumour cells at different temperatures can be systematically explored. It was experimentally found that the survival rate of cancer cells can be greatly reduced while CT-26 cancer cells were heated above 45°C. Besides, localised temperatures increase as high as 59.5°C can be successfully generated in rat livers by using the proposed method. Finally, complete regression of tumour was achieved. The developed method used injectable magnetic nanoparticles and may provide a promising approach for hyperthermia cancer therapy.

Original languageEnglish
Pages (from-to)46-54
Number of pages9
JournalIET Nanobiotechnology
Volume3
Issue number2
DOIs
Publication statusPublished - 2009 Jun 11

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biotechnology
  • Electrical and Electronic Engineering

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