Localized heating of tumor cells utilizing superparamagnetic nanoparticles

Hao Yu Tseng, Chen Yi Lee, Ying Hsia Shih, Xi-Zhang Lin, Gwo Bin Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

This paper presents an investigation of hyperthermia cancer therapy utilizing high-frequency magnetic field to induce a localized temperature increase on tumors by using superparamagnetic nanoparticles. In-vitro and in-vivo experiments showed the feasibility of hyperthermia cancer therapy. The relationship between temperature rise and cell survival rate was also investigated. While CT-26 colon cancer cells were heated above 45°C, the survival rate of cancer cells would be greatly reduced. A temperature increase as high as 59.5°C can be successfully generated in rat livers. In-vivo tests also indicated that hyperthermia cancer therapy using this approach could significantly suppress the growth rate of tumors by utilizing concentrated magnetic nanoparticles and temperature-sensitive hydrogel, which was used to secure the nanoparticles in the target tumor tissue. Furthermore, a feedback temperature control system was successfully developed to keep the nanoparticles at a constant temperature to prevent overheating in the tumors such that a safer and more precise cancer therapy is feasible. The developed technique may be promising for the hyperthermia cancer therapy.

Original languageEnglish
Title of host publication2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings
Pages969-974
Number of pages6
DOIs
Publication statusPublished - 2007 Dec 1
Event2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007 - Hong Kong, China
Duration: 2007 Aug 22007 Aug 5

Publication series

Name2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings

Other

Other2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007
CountryChina
CityHong Kong
Period07-08-0207-08-05

Fingerprint

Tumors
tumors
cancer
Cells
Nanoparticles
hyperthermia
Heating
nanoparticles
therapy
heating
Temperature
temperature
Temperature control
Hydrogels
Liver
Feedback control
Rats
temperature control
liver
Tissue

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering
  • Atomic and Molecular Physics, and Optics

Cite this

Tseng, H. Y., Lee, C. Y., Shih, Y. H., Lin, X-Z., & Lee, G. B. (2007). Localized heating of tumor cells utilizing superparamagnetic nanoparticles. In 2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings (pp. 969-974). [4601345] (2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings). https://doi.org/10.1109/NANO.2007.4601345
Tseng, Hao Yu ; Lee, Chen Yi ; Shih, Ying Hsia ; Lin, Xi-Zhang ; Lee, Gwo Bin. / Localized heating of tumor cells utilizing superparamagnetic nanoparticles. 2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings. 2007. pp. 969-974 (2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings).
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Tseng, HY, Lee, CY, Shih, YH, Lin, X-Z & Lee, GB 2007, Localized heating of tumor cells utilizing superparamagnetic nanoparticles. in 2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings., 4601345, 2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings, pp. 969-974, 2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Hong Kong, China, 07-08-02. https://doi.org/10.1109/NANO.2007.4601345

Localized heating of tumor cells utilizing superparamagnetic nanoparticles. / Tseng, Hao Yu; Lee, Chen Yi; Shih, Ying Hsia; Lin, Xi-Zhang; Lee, Gwo Bin.

2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings. 2007. p. 969-974 4601345 (2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Tseng HY, Lee CY, Shih YH, Lin X-Z, Lee GB. Localized heating of tumor cells utilizing superparamagnetic nanoparticles. In 2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings. 2007. p. 969-974. 4601345. (2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings). https://doi.org/10.1109/NANO.2007.4601345