Long-term hydrophilic modification of PDMS substrate and method for manufacturing the same

Shu-Hui Chen (Inventor)

Research output: Patent

Abstract

The present invention relates to a hydrophilic surface structure of the non-hydrophilic substrate and the manufacturing method for using the same. The hydrophilic substrate surface structure is fabricated by forming an amphiphilic polymer layer, a cross-linked stacking layer, and a hydrophilic layer in sequence on the surface of a non-hydrophilic substrate. For example, the hydrophobic surface of poly(dimethylsiloxane) (PDMS) can be made from hydrophobic to hydrophilic and the hydrophilicity can be retained for a long period of time and resist protein adsorption. The hydrophilic thin films give long term stability to the PDMS surface by resisting hydrophobicity recovery, which is the major problem with PDMS. The disclosed method can further be used in the immobilization of protein and other molecules. This method can also be used for modifying other substrates which suffer problems of surface instability.
Translated title of the contribution非親水性基材之親水性表面結構及其製造方法
Original languageEnglish
Patent number7670686
Publication statusPublished - 2006 Nov 23

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