Long-term prognosis of patients with carbon monoxide poisoning: A nationwide cohort study

Chien Cheng Huang, Min Hsien Chung, Shih Feng Weng, Chih Chiang Chien, Shio Jean Lin, Hung Jung Lin, How Ran Guo, Shih Bin Su, Chien Chin Hsu, Chi Wen Juan

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32 Citations (Scopus)


Background: Carbon monoxide poisoning (COP) often produces severe complications and can be fatal. Because this topic has not been well delineated, we investigated long-term prognoses of patients with COP (COP[+]). Methods: In this retrospective nationwide cohort study, 441 COP[+] patients and 8820 COP[-] controls (120) from 1999 to 2010 were selected from Taiwan's National Health Insurance Research Database. Results: Thirty-seven (8.39%) COP[+] patients and 142 (1.61%) controls died (P<0.0001) during follow-up. Incidence rate ratios (IRR) of death were 5.24 times higher in COP[+] patients than in controls (P<0.0001). The risk of death was particularly high in the first month after COP (IRR: 308.78; 95% confidence interval [CI]: 40.79-2337.56), 1 to 6 months after (IRR: 18.92; 95% CI: 7.69-46.56), and 6-12 months after (IRR: 4.73; 95% CI: 1.02-21.90). After adjusting for age, gender, and selected comorbidities, the hazard ratio of death for COP[+] patients was still 4.097 times higher than for controls. Moreover, older age (≥30 years old), male gender, diabetes mellitus, hypertension, and low income were also independent mortality predictors. Conclusions: COP significantly increases the risk for long-term mortality. Early follow-up and secondary prevention of death are needed for patients with COP.

Original languageEnglish
Article numbere105503
JournalPloS one
Issue number8
Publication statusPublished - 2014 Aug 28

All Science Journal Classification (ASJC) codes

  • General


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