Long‐term Follow‐up and Serological Study after Triple Therapy of Helicobacter pylori‐associated Duodenal Ulcer

Wen‐Ming ‐M Wang, Chang‐Yi ‐Y Chen, Chang‐Ming ‐M Jan, Li‐Tzong ‐T Chen, Daw‐Shyong ‐S Perng, Shiu‐Ru ‐R Lin, Ching-Hsun Liu

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70 Citations (Scopus)

Abstract

Objective: The purpose of this study was to monitor the change of IgG antibodies to Helicobacter pylori during the course of a long‐term follow‐up after the eradication of H. pylori, as well as to evaluate the efficacy of triple therapy in preventing the recurrence of duodenal ulcer (DU). Methods: Twenty‐three DU patients with positive II. pylori were studied; among those patients, 20 ulcers healed after initial treatment of triple therapy. Each patient received a follow‐up endoscopy and biopsy examination every 3 months for 1 yr, or whenever the ulcer symptoms recurred. Serological tests for IgG antibodies were performed with a commercial ELISA. Results: Of the 20 patients with healed ulcers, one dropped out of this study; the recurrence rate of DU at 1 yr was 5% (1/19). There was no recurrence of ulcer in 17 H. pylori‐negative patients and only one recurrence out of two H. pylori ‐ positive patients. After the eradication of H. pylori, the seroconversion rates of IgG were 5%, 21 %, 42%, 76%, and 94% at 0, 3, 6, 9, and 12 months, respectively. After 6 months, 95% (18/19) of the patients in which H. pylori was eradicated had at least a one‐grade fall in IgG titers (P < 0.001). One patient had a relapse of H. pylori which was accompanied with re‐elevating IgG titers. Conclusions: We conclude that seroconversion, which usually occurs after 1 yr, indicates complete eradication of H. pylori. Furthermore, we suggest that the success of the eradication of H. pylori can be judged without endoscopic examination, 8 months after treatment by triple therapy, according to the fall of IgG titers or seroconversion. Re‐elevating IgG titers may be a warning of the possibility of relapse or reinfection of H. pylori.

Original languageEnglish
Pages (from-to)1793-1796
Number of pages4
JournalThe American journal of gastroenterology
Volume89
Issue number10
DOIs
Publication statusPublished - 1994 Jan 1

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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