Loss of epithelial membrane protein-2 expression confers an independent prognosticator in nasopharyngeal carcinoma: A cohort study

Yi Hsien Chen, Li Ching Wu, Wen Ren Wu, Hung Jung Lin, Sung Wei Lee, Ching Yih Lin, Shih Lun Chang, Nan Haw Chow, Hsuan Ying Huang, Chien Feng Li, Han Ping Hsu, Yow Ling Shiue

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Objective: To evaluate the expression of epithelial membrane protein-2 (EMP2) protein and its clinicopathological associations in patients with nasopharyngeal carcinoma. Design: Retrospective population-based cohort study. Setting: This study was based on a biobank in Chi-Mei Medical Center (Tainan, Taiwan) from 1993 to 2002. Participants: Biopsies of 124 consecutive nasopharyngeal carcinoma patients without initial distant metastasis and treated with consistent guidelines were assessed. Immunoexpressions of EMP2 were analysed and the outcomes were correlated with clinicopathological features and patient survivals. Primary and secondary outcome measures: Immunoexpressions of EMP2 were analyzed and the outcomes were correlated with clinicopathological features and patient survivals. Results: Loss of EMP2 expression (49.2%) was correlated with advanced primary tumour (p=0.044), nodal status (p=0.045) and the 7th American Joint Committee on Cancer stage (p=0.027). In multivariate analyses, loss of EMP2 expression emerged as an independent prognosticator for worse disease-specific survival (DSS; p=0.015) and local recurrence-free survival (LRFS; p=0.030), along with the American Joint Committee on Cancer stages IIIeIV (p=0.034, DSS; p=0.023, LRFS). Conclusions: Loss of EMP2 expression is common and associated with adverse prognosticators and might confer tumour aggressiveness through hampering its interaction with specific membrane protein(s) and hence the downstream signal transduction pathway(s).

Original languageEnglish
Article numbere000900
JournalBMJ open
Volume2
Issue number2
DOIs
Publication statusPublished - 2012

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Fingerprint Dive into the research topics of 'Loss of epithelial membrane protein-2 expression confers an independent prognosticator in nasopharyngeal carcinoma: A cohort study'. Together they form a unique fingerprint.

Cite this