Loss of fragile WWOX gene leads to senescence escape and genome instability

Biochemistry, Genetics and Molecular Biology

• Fibroblast 100%
• Genome Instability 100%
• WWOX 100%
• Knockout Mouse 80%
• DNA Damage Response 60%
• P53 40%
• Genetics 20%
• Programmed Cell Death 20%
• P21 20%
• Promoter Region 20%
• P16 20%
• DNA Synthesis 20%
• Oxidative Stress 20%
• Downregulation 20%
• Cell Cycle Progression 20%
• Protein Stability 20%
• Acetylcysteine 20%
• Upregulation 20%
• Cyclin-Dependent Kinase 20%
• DNA-binding Domain 20%
• DNA Damage 20%
• Metaphase Chromosome 20%
• Nuclear DNA 20%
• Ultraviolet Radiation 20%
• Protein Catabolism 20%
• Microsatellite Instability 20%
• CDKN1B 20%

Keyphrases

• Senescence Escape 100%
• Late Passage 40%