Loudness dependence of auditory evoked potentials (LDAEP) correlates with the availability of dopamine transporters and serotonin transporters in healthy volunteers - A two isotopes SPECT study

I-Hui Lee, Yen-Kuang Yang, Po-See Chen, Hui Chun Huang, Tzung Lieh Yeh, Ru-Band Lu, Nan-Tsing Chiu, Wei-Jen Yao, Shih Hsien Lin

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Rationale and objective: Although loudness dependence of auditory evoked potentials (LDAEPs) had been suggested as a noninvasive measure of central serotonin functions, recent studies suggest that LDAEP may be modulated by multiple neuromodulatory systems, such as dopamine. Here, we explore the relationship between LDAEP and dopamine and serotonin in the level of monoamine transporter availability. Methods: Forty-nine healthy volunteers received LDAEP and single-photon emission computed tomography (SPECT) using [99mTc] TRODAT and [123I] ADAM to approximate the availability of dopamine transporters (DATs) and serotonin transporters (SERTs). Results: LDAEP was found to be positively associated with DAT, after adjusting for age and gender, and the log-transformed slope of loudness dependence at Cz was negatively associated with SERT. Conclusion: Our findings provide further evidence for the possible involvement of dopamine and serotonins in the genesis of LDAEP.

Original languageEnglish
Pages (from-to)617-624
Number of pages8
JournalPsychopharmacology
Volume214
Issue number3
DOIs
Publication statusPublished - 2011 Apr 1

All Science Journal Classification (ASJC) codes

  • Pharmacology

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