Low azeotropic solvent sealing of PMMA microfluidic devices

Che Hsin Lin; Lung Ming Fu; Chien Hsiung Tsai; Chien Hsiang Chao; Che Wei Lan

Low azeotropic solvent sealing of PMMA microfluidic devices

Che Hsin Lin, Lung Ming Fu, Chien Hsiung Tsai, Chien Hsiang Chao, Che Wei Lan

Department of Engineering Science

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Citations (Scopus)

Abstract

A new method for sealing PMMA-based microfluidic devices utilizing low azeotropic solvent, named DE-20, is developed. The bonding process can be achieved in 7 min at room temperature and can successfully bond microchannels as small as 40 μm in width without clogging. Results show the bonding strength and the increased roughness of the surface after the bonding process are 3.8 ±0.31 MPa (n = 8) and 10 nm respectively. The achieved bonding strength is 17-fold larger than the conventional thermal bonding. Furthermore, the proposed method can seal a 3-mm wide microfluidic channel without collapsing the channels since no heating process is required in the bonding process. The bonding performance is confirmed by using a zigzag type passive microfluidic mixer. Results present a high mixing efficiency can be achieved under a high driven pressure. More importantly, no leakage is observed under such high pressure.

Original language	English
Title of host publication	TRANSDUCERS '05 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems - Digest of Technical Papers
Pages	944-947
Number of pages	4
Publication status	Published - 2005 Nov 9
Event	13th International Conference on Solid-State Sensors and Actuators and Microsystems, TRANSDUCERS '05 - Seoul, Korea, Republic of Duration: 2005 Jun 5 → 2005 Jun 9

Publication series

Name	Digest of Technical Papers - International Conference on Solid State Sensors and Actuators and Microsystems, TRANSDUCERS '05
Volume	1

Other

Other	13th International Conference on Solid-State Sensors and Actuators and Microsystems, TRANSDUCERS '05
Country	Korea, Republic of
City	Seoul
Period	05-06-05 → 05-06-09

All Science Journal Classification (ASJC) codes

Engineering(all)

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Lin, C. H., Fu, L. M., Tsai, C. H., Chao, C. H., & Lan, C. W. (2005). Low azeotropic solvent sealing of PMMA microfluidic devices. In TRANSDUCERS '05 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems - Digest of Technical Papers (pp. 944-947). [2E4.123] (Digest of Technical Papers - International Conference on Solid State Sensors and Actuators and Microsystems, TRANSDUCERS '05; Vol. 1).

Lin, Che Hsin ; Fu, Lung Ming ; Tsai, Chien Hsiung ; Chao, Chien Hsiang ; Lan, Che Wei. / Low azeotropic solvent sealing of PMMA microfluidic devices. TRANSDUCERS '05 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems - Digest of Technical Papers. 2005. pp. 944-947 (Digest of Technical Papers - International Conference on Solid State Sensors and Actuators and Microsystems, TRANSDUCERS '05).

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title = "Low azeotropic solvent sealing of PMMA microfluidic devices",

abstract = "A new method for sealing PMMA-based microfluidic devices utilizing low azeotropic solvent, named DE-20, is developed. The bonding process can be achieved in 7 min at room temperature and can successfully bond microchannels as small as 40 μm in width without clogging. Results show the bonding strength and the increased roughness of the surface after the bonding process are 3.8 ±0.31 MPa (n = 8) and 10 nm respectively. The achieved bonding strength is 17-fold larger than the conventional thermal bonding. Furthermore, the proposed method can seal a 3-mm wide microfluidic channel without collapsing the channels since no heating process is required in the bonding process. The bonding performance is confirmed by using a zigzag type passive microfluidic mixer. Results present a high mixing efficiency can be achieved under a high driven pressure. More importantly, no leakage is observed under such high pressure.",

author = "Lin, {Che Hsin} and Fu, {Lung Ming} and Tsai, {Chien Hsiung} and Chao, {Chien Hsiang} and Lan, {Che Wei}",

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Lin, CH, Fu, LM, Tsai, CH, Chao, CH & Lan, CW 2005, Low azeotropic solvent sealing of PMMA microfluidic devices. in TRANSDUCERS '05 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems - Digest of Technical Papers., 2E4.123, Digest of Technical Papers - International Conference on Solid State Sensors and Actuators and Microsystems, TRANSDUCERS '05, vol. 1, pp. 944-947, 13th International Conference on Solid-State Sensors and Actuators and Microsystems, TRANSDUCERS '05, Seoul, Korea, Republic of, 05-06-05.

Low azeotropic solvent sealing of PMMA microfluidic devices. / Lin, Che Hsin; Fu, Lung Ming; Tsai, Chien Hsiung; Chao, Chien Hsiang; Lan, Che Wei.

TRANSDUCERS '05 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems - Digest of Technical Papers. 2005. p. 944-947 2E4.123 (Digest of Technical Papers - International Conference on Solid State Sensors and Actuators and Microsystems, TRANSDUCERS '05; Vol. 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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T1 - Low azeotropic solvent sealing of PMMA microfluidic devices

AU - Lin, Che Hsin

AU - Fu, Lung Ming

AU - Tsai, Chien Hsiung

AU - Chao, Chien Hsiang

AU - Lan, Che Wei

PY - 2005/11/9

Y1 - 2005/11/9

N2 - A new method for sealing PMMA-based microfluidic devices utilizing low azeotropic solvent, named DE-20, is developed. The bonding process can be achieved in 7 min at room temperature and can successfully bond microchannels as small as 40 μm in width without clogging. Results show the bonding strength and the increased roughness of the surface after the bonding process are 3.8 ±0.31 MPa (n = 8) and 10 nm respectively. The achieved bonding strength is 17-fold larger than the conventional thermal bonding. Furthermore, the proposed method can seal a 3-mm wide microfluidic channel without collapsing the channels since no heating process is required in the bonding process. The bonding performance is confirmed by using a zigzag type passive microfluidic mixer. Results present a high mixing efficiency can be achieved under a high driven pressure. More importantly, no leakage is observed under such high pressure.

AB - A new method for sealing PMMA-based microfluidic devices utilizing low azeotropic solvent, named DE-20, is developed. The bonding process can be achieved in 7 min at room temperature and can successfully bond microchannels as small as 40 μm in width without clogging. Results show the bonding strength and the increased roughness of the surface after the bonding process are 3.8 ±0.31 MPa (n = 8) and 10 nm respectively. The achieved bonding strength is 17-fold larger than the conventional thermal bonding. Furthermore, the proposed method can seal a 3-mm wide microfluidic channel without collapsing the channels since no heating process is required in the bonding process. The bonding performance is confirmed by using a zigzag type passive microfluidic mixer. Results present a high mixing efficiency can be achieved under a high driven pressure. More importantly, no leakage is observed under such high pressure.

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T3 - Digest of Technical Papers - International Conference on Solid State Sensors and Actuators and Microsystems, TRANSDUCERS '05

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BT - TRANSDUCERS '05 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems - Digest of Technical Papers

T2 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems, TRANSDUCERS '05

Y2 - 5 June 2005 through 9 June 2005

ER -

Lin CH, Fu LM, Tsai CH, Chao CH, Lan CW. Low azeotropic solvent sealing of PMMA microfluidic devices. In TRANSDUCERS '05 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems - Digest of Technical Papers. 2005. p. 944-947. 2E4.123. (Digest of Technical Papers - International Conference on Solid State Sensors and Actuators and Microsystems, TRANSDUCERS '05).