Low Dose of X-Ray-Excited Long-Lasting Luminescent Concave Nanocubes in Highly Passive Targeting Deep-Seated Hepatic Tumors

Zheng Zhe Chen; Liu Chun Wang; Divinah Manoharan; Chin Lai Lee; Lai Chin Wu; Wan Ting Huang; Eng Yen Huang; Chia Hao Su; Hwo Shuenn Sheu; Chen Sheng Yeh

doi:10.1002/adma.201905087

Low Dose of X-Ray-Excited Long-Lasting Luminescent Concave Nanocubes in Highly Passive Targeting Deep-Seated Hepatic Tumors

Zheng Zhe Chen, Liu Chun Wang, Divinah Manoharan, Chin Lai Lee, Lai Chin Wu, Wan Ting Huang, Eng Yen Huang, Chia Hao Su, Hwo Shuenn Sheu, Chen Sheng Yeh

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Chromium-doped zinc gallate, ZnGa₂O₄:Cr³⁺ (ZGC), is viewed as a long-lasting luminescence (LLL) phosphor that can avoid tissue autofluorescence interference for in vivo imaging detection. ZGC is a cubic spinel structure, a typical agglomerative or clustered morphology lacking a defined cubic shape, but a sphere-like feature is commonly obtained for the nanometric ZGC. The substantial challenge remains achieving a well-defined cubic feature in nanoscale. The process by which dispersed and well-defined concave cubic ZGC is obtained is described, exhibiting much stronger LLL in UV and X-ray excitation for the dispersed cubic ZGC compared with the agglomerative form that cannot be excited using X-rays with a low dose of 0.5 Gy. The cubic ZGC reveals a specific accumulation in liver and 0.5 Gy used at the end of X-ray excitation is sufficient for imaging of deep-seated hepatic tumors. The ZGC nanocubes show highly passive targeting of orthotopic hepatic tumors.

Original language	English
Article number	1905087
Journal	Advanced Materials
Volume	31
Issue number	49
DOIs	https://doi.org/10.1002/adma.201905087
Publication status	Published - 2019 Dec 1

All Science Journal Classification (ASJC) codes

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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@article{0866b8c1ead84da8b62e7aa23a1d20f8,

title = "Low Dose of X-Ray-Excited Long-Lasting Luminescent Concave Nanocubes in Highly Passive Targeting Deep-Seated Hepatic Tumors",

abstract = "Chromium-doped zinc gallate, ZnGa2O4:Cr3+ (ZGC), is viewed as a long-lasting luminescence (LLL) phosphor that can avoid tissue autofluorescence interference for in vivo imaging detection. ZGC is a cubic spinel structure, a typical agglomerative or clustered morphology lacking a defined cubic shape, but a sphere-like feature is commonly obtained for the nanometric ZGC. The substantial challenge remains achieving a well-defined cubic feature in nanoscale. The process by which dispersed and well-defined concave cubic ZGC is obtained is described, exhibiting much stronger LLL in UV and X-ray excitation for the dispersed cubic ZGC compared with the agglomerative form that cannot be excited using X-rays with a low dose of 0.5 Gy. The cubic ZGC reveals a specific accumulation in liver and 0.5 Gy used at the end of X-ray excitation is sufficient for imaging of deep-seated hepatic tumors. The ZGC nanocubes show highly passive targeting of orthotopic hepatic tumors.",

author = "Chen, {Zheng Zhe} and Wang, {Liu Chun} and Divinah Manoharan and Lee, {Chin Lai} and Wu, {Lai Chin} and Huang, {Wan Ting} and Huang, {Eng Yen} and Su, {Chia Hao} and Sheu, {Hwo Shuenn} and Yeh, {Chen Sheng}",

note = "Funding Information: Z.-Z.C. and L.-C.W. contributed equally to this work. C.-S. Yeh appreciates the financial support from the Ministry of Science and Technology, Taiwan (MOST107-2113-M-006-004-MY2). C.-H. Su thanks the financial support by the Ministry of Science and Technology, Taiwan (MOST106-2314-B-182A-008-MY3) and the Chang Gung Medical Foundation (CMRPG8I0141-3). Additional financially support was provided by the Center of Applied Nanomedicine, National Cheng Kung University, under the Featured Areas Research Center Program within the framework of the Higher Education Sprout Project of the Ministry of Education (MOE) in Taiwan. Publisher Copyright: {\textcopyright} 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2019",

month = dec,

day = "1",

doi = "10.1002/adma.201905087",

language = "English",

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T1 - Low Dose of X-Ray-Excited Long-Lasting Luminescent Concave Nanocubes in Highly Passive Targeting Deep-Seated Hepatic Tumors

AU - Chen, Zheng Zhe

AU - Wang, Liu Chun

AU - Manoharan, Divinah

AU - Lee, Chin Lai

AU - Wu, Lai Chin

AU - Huang, Wan Ting

AU - Huang, Eng Yen

AU - Su, Chia Hao

AU - Sheu, Hwo Shuenn

AU - Yeh, Chen Sheng

N1 - Funding Information: Z.-Z.C. and L.-C.W. contributed equally to this work. C.-S. Yeh appreciates the financial support from the Ministry of Science and Technology, Taiwan (MOST107-2113-M-006-004-MY2). C.-H. Su thanks the financial support by the Ministry of Science and Technology, Taiwan (MOST106-2314-B-182A-008-MY3) and the Chang Gung Medical Foundation (CMRPG8I0141-3). Additional financially support was provided by the Center of Applied Nanomedicine, National Cheng Kung University, under the Featured Areas Research Center Program within the framework of the Higher Education Sprout Project of the Ministry of Education (MOE) in Taiwan. Publisher Copyright: © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Chromium-doped zinc gallate, ZnGa2O4:Cr3+ (ZGC), is viewed as a long-lasting luminescence (LLL) phosphor that can avoid tissue autofluorescence interference for in vivo imaging detection. ZGC is a cubic spinel structure, a typical agglomerative or clustered morphology lacking a defined cubic shape, but a sphere-like feature is commonly obtained for the nanometric ZGC. The substantial challenge remains achieving a well-defined cubic feature in nanoscale. The process by which dispersed and well-defined concave cubic ZGC is obtained is described, exhibiting much stronger LLL in UV and X-ray excitation for the dispersed cubic ZGC compared with the agglomerative form that cannot be excited using X-rays with a low dose of 0.5 Gy. The cubic ZGC reveals a specific accumulation in liver and 0.5 Gy used at the end of X-ray excitation is sufficient for imaging of deep-seated hepatic tumors. The ZGC nanocubes show highly passive targeting of orthotopic hepatic tumors.

AB - Chromium-doped zinc gallate, ZnGa2O4:Cr3+ (ZGC), is viewed as a long-lasting luminescence (LLL) phosphor that can avoid tissue autofluorescence interference for in vivo imaging detection. ZGC is a cubic spinel structure, a typical agglomerative or clustered morphology lacking a defined cubic shape, but a sphere-like feature is commonly obtained for the nanometric ZGC. The substantial challenge remains achieving a well-defined cubic feature in nanoscale. The process by which dispersed and well-defined concave cubic ZGC is obtained is described, exhibiting much stronger LLL in UV and X-ray excitation for the dispersed cubic ZGC compared with the agglomerative form that cannot be excited using X-rays with a low dose of 0.5 Gy. The cubic ZGC reveals a specific accumulation in liver and 0.5 Gy used at the end of X-ray excitation is sufficient for imaging of deep-seated hepatic tumors. The ZGC nanocubes show highly passive targeting of orthotopic hepatic tumors.

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DO - 10.1002/adma.201905087

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ER -

Low Dose of X-Ray-Excited Long-Lasting Luminescent Concave Nanocubes in Highly Passive Targeting Deep-Seated Hepatic Tumors

Abstract

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