Low-dose systemic bupivacaine prevents the development of allodynia after thoracotomy in rats

Jin Woo Shin, Carlo Pancaro, Chi-Fei Wang, Peter Gerner

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

BACKGROUND: Chronic pain after thoracotomy has been recently reproduced in a rat model that allows investigation of the effect of drugs that might reduce the incidence of allodynia after thoracotomy. Previous studies suggest that intrathecal or systemic morphine, clonidine, neostigmine, and gabapentin reduce the incidence of allodynia in the rat postthoracotomy pain model. Our purpose was to test whether intercostal and systemic injection of bupivacaine prevented the development of allodynia in an animal model of chronic intercostal neuropathic pain. METHODS: Male Sprague-Dawley rats were anesthetized and the right 4th and 5th ribs surgically exposed. The pleura were opened and the ribs were retracted for 1 h. Intercostal or systemic bupivacaine 1 mg (0.2 mL at 0.5%) was injected before and after surgery, or before surgery; a control group underwent rib retraction and did not receive any drug. Rats were tested for mechanical allodynia at a predetermined area around the incision site during the 3 wk after surgery. RESULTS: Allodynia developed in 43% of the animals that did not receive bupivacaine (control group); in contrast, allodynia developed in only 6%, 12%, and 12% of those animals that received intercostal bupivacaine before surgery, after surgery, or systemically before surgery, respectively. DISCUSSION:: Previous studies suggest that allodynia after rib retraction can be prevented by opioids, α2-adrenergic agonists, neostigmine, and gabapentin. The current results suggest that bupivacaine is effective in preventing mechanical allodynia, whether given by intercostal injection before or after surgery, or systemically before surgery.

Original languageEnglish
Pages (from-to)1587-1591
Number of pages5
JournalAnesthesia and analgesia
Volume107
Issue number5
DOIs
Publication statusPublished - 2008 Jan 1

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Bupivacaine
Hyperalgesia
Thoracotomy
Ribs
Neostigmine
Adrenergic Agonists
Control Groups
Injections
Pleura
Incidence
Clonidine
Neuralgia
Chronic Pain
Pharmaceutical Preparations
Morphine
Opioid Analgesics
Sprague Dawley Rats
Animal Models
Pain

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

Shin, Jin Woo ; Pancaro, Carlo ; Wang, Chi-Fei ; Gerner, Peter. / Low-dose systemic bupivacaine prevents the development of allodynia after thoracotomy in rats. In: Anesthesia and analgesia. 2008 ; Vol. 107, No. 5. pp. 1587-1591.
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title = "Low-dose systemic bupivacaine prevents the development of allodynia after thoracotomy in rats",
abstract = "BACKGROUND: Chronic pain after thoracotomy has been recently reproduced in a rat model that allows investigation of the effect of drugs that might reduce the incidence of allodynia after thoracotomy. Previous studies suggest that intrathecal or systemic morphine, clonidine, neostigmine, and gabapentin reduce the incidence of allodynia in the rat postthoracotomy pain model. Our purpose was to test whether intercostal and systemic injection of bupivacaine prevented the development of allodynia in an animal model of chronic intercostal neuropathic pain. METHODS: Male Sprague-Dawley rats were anesthetized and the right 4th and 5th ribs surgically exposed. The pleura were opened and the ribs were retracted for 1 h. Intercostal or systemic bupivacaine 1 mg (0.2 mL at 0.5{\%}) was injected before and after surgery, or before surgery; a control group underwent rib retraction and did not receive any drug. Rats were tested for mechanical allodynia at a predetermined area around the incision site during the 3 wk after surgery. RESULTS: Allodynia developed in 43{\%} of the animals that did not receive bupivacaine (control group); in contrast, allodynia developed in only 6{\%}, 12{\%}, and 12{\%} of those animals that received intercostal bupivacaine before surgery, after surgery, or systemically before surgery, respectively. DISCUSSION:: Previous studies suggest that allodynia after rib retraction can be prevented by opioids, α2-adrenergic agonists, neostigmine, and gabapentin. The current results suggest that bupivacaine is effective in preventing mechanical allodynia, whether given by intercostal injection before or after surgery, or systemically before surgery.",
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Low-dose systemic bupivacaine prevents the development of allodynia after thoracotomy in rats. / Shin, Jin Woo; Pancaro, Carlo; Wang, Chi-Fei; Gerner, Peter.

In: Anesthesia and analgesia, Vol. 107, No. 5, 01.01.2008, p. 1587-1591.

Research output: Contribution to journalArticle

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T1 - Low-dose systemic bupivacaine prevents the development of allodynia after thoracotomy in rats

AU - Shin, Jin Woo

AU - Pancaro, Carlo

AU - Wang, Chi-Fei

AU - Gerner, Peter

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N2 - BACKGROUND: Chronic pain after thoracotomy has been recently reproduced in a rat model that allows investigation of the effect of drugs that might reduce the incidence of allodynia after thoracotomy. Previous studies suggest that intrathecal or systemic morphine, clonidine, neostigmine, and gabapentin reduce the incidence of allodynia in the rat postthoracotomy pain model. Our purpose was to test whether intercostal and systemic injection of bupivacaine prevented the development of allodynia in an animal model of chronic intercostal neuropathic pain. METHODS: Male Sprague-Dawley rats were anesthetized and the right 4th and 5th ribs surgically exposed. The pleura were opened and the ribs were retracted for 1 h. Intercostal or systemic bupivacaine 1 mg (0.2 mL at 0.5%) was injected before and after surgery, or before surgery; a control group underwent rib retraction and did not receive any drug. Rats were tested for mechanical allodynia at a predetermined area around the incision site during the 3 wk after surgery. RESULTS: Allodynia developed in 43% of the animals that did not receive bupivacaine (control group); in contrast, allodynia developed in only 6%, 12%, and 12% of those animals that received intercostal bupivacaine before surgery, after surgery, or systemically before surgery, respectively. DISCUSSION:: Previous studies suggest that allodynia after rib retraction can be prevented by opioids, α2-adrenergic agonists, neostigmine, and gabapentin. The current results suggest that bupivacaine is effective in preventing mechanical allodynia, whether given by intercostal injection before or after surgery, or systemically before surgery.

AB - BACKGROUND: Chronic pain after thoracotomy has been recently reproduced in a rat model that allows investigation of the effect of drugs that might reduce the incidence of allodynia after thoracotomy. Previous studies suggest that intrathecal or systemic morphine, clonidine, neostigmine, and gabapentin reduce the incidence of allodynia in the rat postthoracotomy pain model. Our purpose was to test whether intercostal and systemic injection of bupivacaine prevented the development of allodynia in an animal model of chronic intercostal neuropathic pain. METHODS: Male Sprague-Dawley rats were anesthetized and the right 4th and 5th ribs surgically exposed. The pleura were opened and the ribs were retracted for 1 h. Intercostal or systemic bupivacaine 1 mg (0.2 mL at 0.5%) was injected before and after surgery, or before surgery; a control group underwent rib retraction and did not receive any drug. Rats were tested for mechanical allodynia at a predetermined area around the incision site during the 3 wk after surgery. RESULTS: Allodynia developed in 43% of the animals that did not receive bupivacaine (control group); in contrast, allodynia developed in only 6%, 12%, and 12% of those animals that received intercostal bupivacaine before surgery, after surgery, or systemically before surgery, respectively. DISCUSSION:: Previous studies suggest that allodynia after rib retraction can be prevented by opioids, α2-adrenergic agonists, neostigmine, and gabapentin. The current results suggest that bupivacaine is effective in preventing mechanical allodynia, whether given by intercostal injection before or after surgery, or systemically before surgery.

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