Low levels of high-density lipoprotein cholesterol in patients with atherosclerotic stroke: A prospective cohort study

Poh Shiow Yeh, Chun Ming Yang, Sheng Hsiang Lin, Wei Ming Wang, Po Sheng Chen, Ting Hsing Chao, Huey Juan Lin, Kao Chang Lin, Chia Yu Chang, Tain Junn Cheng, Yi Heng Li

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


Objective: The purpose of this study was to evaluate the influence of baseline high-density lipoprotein cholesterol (HDL-C) on initial stroke severity and clinical outcomes in acute ischemic stroke. Methods: From August 2006 through December 2011, patients with acute atherosclerotic ischemic stroke were included. Total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C) and HDL-C were checked and National Institutes of Health Stroke Scale (NIHSS) scores were obtained at admission. The primary outcomes were a composite end point of all-cause mortality, recurrent stroke, or occurrence of ischemic heart disease during follow-up. Results: Overall, 3093 subjects (mean age 66.8 years) were included and 675 patients (22%) had low HDL-C (≤35mg/dL) at admission. These patients had higher NIHSS scores. After adjusting for all clinical factors in multivariate logistic analysis, low HDL-C at admission (OR, 1.79, 95% CI, 1.40-2.29) was significantly associated with higher stroke severity (NIHSS score>6). During the follow-up period, 280 patients (9%) developed one of the components of the composite end point, including 76 (11.3%) in patients with low HDL-C and 204 (8.4%) in patients with normal HDL-C at admission (p<0.001). In multivariate Cox regression analysis, after adjusting for all clinical factors, low HDL-C at admission (HR, 1.41, 95% CI, 1.02-1.95) was a significant independent predictor of the composite end point. Conclusions: Low baseline HDL-C (≤35mg/dL) at admission was associated with higher stroke severity and poor clinical outcome during follow-up in patients with atherosclerotic ischemic stroke.

Original languageEnglish
Pages (from-to)472-477
Number of pages6
Issue number2
Publication statusPublished - 2013 Jun

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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