Low seroprotection against preseasonal influenza local strains in children might predict the upcoming epidemic influenza strains

Wei Ju Su, Pei Lan Shao, Ming Tsan Liu, Ding Ping Liu, Kuo Chin Huang, Luan Yin Chang, Chun Yi Lu, Jen Ren Wang, Shin Ru Shih, Daniel Tsung Ning Huang, Hsin Chi, Li Min Huang

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background. Our objective was to determine the serological signals that indicated the possible dominant circulating influenza virus subtypes for the coming influenza seasons. Methods. Healthy children 6 months through 5 years of age, adults 18-60 years of age, and elderly adults >60 years of age were recruited to receive seasonal trivalent inactivated influenza vaccinations from October through December during the 2006-2007 and 2008-2009 seasons. Paired serum samples were collected at baseline and at 3 weeks after vaccination. Using a hemagglutination inhibition (HAI) assay, we measured antibody responses to local influenza strains circulating early in October, before each winter influenza season. Results. A total of 301 subjects were tested for antibody to local strains (80, 120, and 101 subjects in the 2006-2007, 2007-2008, and 2008-2009 seasons, respectively). The dominant winter influenza strains in Taiwan were B/Malaysia/2506/2004-like in the 2006-2007 season, A/Brisbane/59/2007-like virus (H1N1) in the 2007-2008 season, and A/Brisbane/59/2007-like virus (H1N1) in the 2008-2009 season. The group with the lowest number of subjects with an HAI titer of ≥40 at baseline was children with antibody against the B/Taiwan/0050/2006 in the 2006-2007 season, A/Taiwan/785/2006 (H1N1) in 2007-2008 season, and A/Taiwan/951/2007 (H1N1) in 2008- 2009 season. The emergence of these viruses correlated well with the circulating influenza subtype in the following winter peak seasons. Conclusions. Low seroprotection rate among children against a specific locally circulating influenza strain might predict the dominantly circulating subtype of influenza virus in the coming winter season. A year-end preseasonal serological survey of children could provide valuable information about the possible circulating strain and tailor the disease-control strategy accordingly.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalClinical Infectious Diseases
Issue number2
Publication statusPublished - 2010 Jul 15

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases


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