Lower availability of midbrain serotonin transporter between healthy subjects with and without a family history of major depressive disorder - a preliminary two-ligand SPECT study

Pei-Chun Hsieh, Kao-Ching Chen, T. L. Yeh, I-Hui Lee, Po-See Chen, Wei-Jen Yao, Nan-Tsing Chiu, C. C. Chen, M. H. Liao, Yen-Kuang Yang

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Abstract

PURPOSE: Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depressive disorder (MDD) who are in a depressed state in comparison with healthy controls. In addition, a family history of depression is a potent risk factor for developing depression, and inherited vulnerability to serotonergic and dopaminergic dysfunction is suspected in this. The aim of this study was to examine the availabilities of midbrain SERT and striatal DAT in healthy subjects with and without a first-degree family history of MDD.

METHODS: Eight healthy subjects with first-degree relatives with MDD and 16 sex- and age-matched healthy controls were recruited. The availabilities of SERT and DAT were approximated using SPECT, employing [¹²³I] 2-((2-((dimethylamino) methyl) phenyl)thio)-5-iodophenylamine (ADAM) and [(⁹⁹m)Tc] TRODAT-1 as the ligands, respectively. There are missing data for one participant with a first-degree family history of MDD from the ADAM study, due to a lack of the radio-ligand at the time of experiment.

RESULTS: SERT availability in the midbrain was significantly lower in subjects with a first-degree family history of MDD than in healthy subjects. However, DAT availability was no different between two groups.

CONCLUSIONS: The results with regard to the midbrain SERT level suggest the heritability of MDD.

Original languageEnglish
Pages (from-to)414-418
Number of pages5
JournalEuropean psychiatry : the journal of the Association of European Psychiatrists
Volume29
Issue number7
DOIs
Publication statusPublished - 2014 Sep 1

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Serotonin Plasma Membrane Transport Proteins
Major Depressive Disorder
Mesencephalon
Single-Photon Emission-Computed Tomography
Healthy Volunteers
Dopamine Plasma Membrane Transport Proteins
Ligands
Depression
Corpus Striatum
Radio

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

Cite this

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title = "Lower availability of midbrain serotonin transporter between healthy subjects with and without a family history of major depressive disorder - a preliminary two-ligand SPECT study",
abstract = "PURPOSE: Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depressive disorder (MDD) who are in a depressed state in comparison with healthy controls. In addition, a family history of depression is a potent risk factor for developing depression, and inherited vulnerability to serotonergic and dopaminergic dysfunction is suspected in this. The aim of this study was to examine the availabilities of midbrain SERT and striatal DAT in healthy subjects with and without a first-degree family history of MDD.METHODS: Eight healthy subjects with first-degree relatives with MDD and 16 sex- and age-matched healthy controls were recruited. The availabilities of SERT and DAT were approximated using SPECT, employing [¹²³I] 2-((2-((dimethylamino) methyl) phenyl)thio)-5-iodophenylamine (ADAM) and [(⁹⁹m)Tc] TRODAT-1 as the ligands, respectively. There are missing data for one participant with a first-degree family history of MDD from the ADAM study, due to a lack of the radio-ligand at the time of experiment.RESULTS: SERT availability in the midbrain was significantly lower in subjects with a first-degree family history of MDD than in healthy subjects. However, DAT availability was no different between two groups.CONCLUSIONS: The results with regard to the midbrain SERT level suggest the heritability of MDD.",
author = "Pei-Chun Hsieh and Kao-Ching Chen and Yeh, {T. L.} and I-Hui Lee and Po-See Chen and Wei-Jen Yao and Nan-Tsing Chiu and Chen, {C. C.} and Liao, {M. H.} and Yen-Kuang Yang",
year = "2014",
month = "9",
day = "1",
doi = "10.1016/j.eurpsy.2013.11.004",
language = "English",
volume = "29",
pages = "414--418",
journal = "European Psychiatry",
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publisher = "Elsevier Masson",
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TY - JOUR

T1 - Lower availability of midbrain serotonin transporter between healthy subjects with and without a family history of major depressive disorder - a preliminary two-ligand SPECT study

AU - Hsieh, Pei-Chun

AU - Chen, Kao-Ching

AU - Yeh, T. L.

AU - Lee, I-Hui

AU - Chen, Po-See

AU - Yao, Wei-Jen

AU - Chiu, Nan-Tsing

AU - Chen, C. C.

AU - Liao, M. H.

AU - Yang, Yen-Kuang

PY - 2014/9/1

Y1 - 2014/9/1

N2 - PURPOSE: Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depressive disorder (MDD) who are in a depressed state in comparison with healthy controls. In addition, a family history of depression is a potent risk factor for developing depression, and inherited vulnerability to serotonergic and dopaminergic dysfunction is suspected in this. The aim of this study was to examine the availabilities of midbrain SERT and striatal DAT in healthy subjects with and without a first-degree family history of MDD.METHODS: Eight healthy subjects with first-degree relatives with MDD and 16 sex- and age-matched healthy controls were recruited. The availabilities of SERT and DAT were approximated using SPECT, employing [¹²³I] 2-((2-((dimethylamino) methyl) phenyl)thio)-5-iodophenylamine (ADAM) and [(⁹⁹m)Tc] TRODAT-1 as the ligands, respectively. There are missing data for one participant with a first-degree family history of MDD from the ADAM study, due to a lack of the radio-ligand at the time of experiment.RESULTS: SERT availability in the midbrain was significantly lower in subjects with a first-degree family history of MDD than in healthy subjects. However, DAT availability was no different between two groups.CONCLUSIONS: The results with regard to the midbrain SERT level suggest the heritability of MDD.

AB - PURPOSE: Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depressive disorder (MDD) who are in a depressed state in comparison with healthy controls. In addition, a family history of depression is a potent risk factor for developing depression, and inherited vulnerability to serotonergic and dopaminergic dysfunction is suspected in this. The aim of this study was to examine the availabilities of midbrain SERT and striatal DAT in healthy subjects with and without a first-degree family history of MDD.METHODS: Eight healthy subjects with first-degree relatives with MDD and 16 sex- and age-matched healthy controls were recruited. The availabilities of SERT and DAT were approximated using SPECT, employing [¹²³I] 2-((2-((dimethylamino) methyl) phenyl)thio)-5-iodophenylamine (ADAM) and [(⁹⁹m)Tc] TRODAT-1 as the ligands, respectively. There are missing data for one participant with a first-degree family history of MDD from the ADAM study, due to a lack of the radio-ligand at the time of experiment.RESULTS: SERT availability in the midbrain was significantly lower in subjects with a first-degree family history of MDD than in healthy subjects. However, DAT availability was no different between two groups.CONCLUSIONS: The results with regard to the midbrain SERT level suggest the heritability of MDD.

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JF - European Psychiatry

SN - 0924-9338

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