Lung nodule biopsy guided using a 30 MHz ultrasound transducer: in vitro study

Ben Kreager, Sunho Moon, Josh Mitchell, Huaiyu Wu, Chang Peng, Marie Muller, Chih Chung Huang, Xiaoning Jiang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)


Ultrasound is often favored in biopsy guidance since it is non-ionizing, inexpensive, portable, and has a high frame rate. However, imaging probes that operate at a low frequency may not be able to differentiate between tiny targets and surrounding tissues clearly, and at a high frequency, it suffers from tissue scattering and signals attenuation, which is hard to image deeper targets such as lung tissues. In this study, we developed a biopsy needle (with a size of 18 G) integrated with a 30 MHz high-frequency ultrasound transducer (axial resolution: ~ 100 µm) for the lung nodule biopsy in vitro test. To mimic contrasting biological tissues, a melamine foam-gelatin phantom was developed. With an advancing step of 0.5 mm, the distance from the biopsy needle to the gelatin-foam boundary was estimated by the speed of sound in gelatin and the time-of-flight of the echo signal. The results showed that the 30 MHz ultrasound transducer can map the geometry of the gelatin-foam boundary, indicating the capability of distinguishing tumor and healthy lung tissue with this ultrasound-guided biopsy technique.

Original languageEnglish
Title of host publicationHealth Monitoring of Structural and Biological Systems XVII
EditorsPaul Fromme, Zhongqing Su
ISBN (Electronic)9781510660830
Publication statusPublished - 2023
EventHealth Monitoring of Structural and Biological Systems XVII 2023 - Long Beach, United States
Duration: 2023 Mar 132023 Mar 16

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X


ConferenceHealth Monitoring of Structural and Biological Systems XVII 2023
Country/TerritoryUnited States
CityLong Beach

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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